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The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study
BackgroundPreclinical evidence shows that short-term fasting (STF) protects healthy cells against side effects of chemotherapy and makes cancer cells more vulnerable to it. This pilot study examinesExpand
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Analysis of radiation-induced chromosomal aberrations using telomeric and centromeric PNA probes.
PURPOSE To generate dose-response curves for X-ray-induced chromosomal aberrations analysed in human blood lymphocytes using telomeric and centromeric peptide nucleic acid (PNA) probes. MATERIALSExpand
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Recent developments in the assessment of chromosomal damage.
Ionizing radiation and restriction endonucleases are very efficient in inducing chromosomal aberrations (CAs). These aberrations are mainly consequences of misrepair of DNA double-strand breaksExpand
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Detection of chromosomal aberrations by fluorescence in situ hybridization in the first three postirradiation divisions of human lymphocytes.
Chromosomal aberrations in human lymphocytes were analyzed by fluorescence in situ hybridization (FISH) in the first 3 postirradiation (0 and 2 Gy) divisions. Cells were grown in the presence ofExpand
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Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations.
Chromosome translocations (stable aberrations) can persist longer during cellular proliferation than dicentrics (unstable aberrations). It is important to know the kinetics of the elimination ofExpand
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Detection of incomplete exchanges and interstitial fragments in X-irradiated human lymphocytes using a telomeric PNA probe.
PURPOSE The detection of incomplete exchanges and interstitial fragments by fluorescence in situ hybridization using a telomeric peptide nucleic acid (PNA) probe. MATERIALS AND METHODS IsolatedExpand
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Impact of radiation quality on the spectrum of induced chromosome exchange aberrations
Purpose: To study the impact of radiation quality on the spectrum of chromosome exchange aberrations in human lymphocytes using chromosome arm-specific and telomeric probes. The analysis is focusedExpand
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Current cytogenetic methods for detecting exposure and effects of mutagens and carcinogens.
Most mutagens and genotoxic carcinogens are efficient inducers of chromosomal alterations in exposed cells. Two important classes of aberrations, namely structural and numerical, are recognized andExpand
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Involvement of Mouse Rev3 in Tolerance of Endogenous and Exogenous DNA Damage
ABSTRACT The Rev3 gene of Saccharomyces cerevisiae encodes the catalytic subunit of DNA polymerase ζ that is implicated in mutagenic translesion synthesis of damaged DNA. To investigate the functionExpand
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Xenobiotic metabolism in differentiated human bronchial epithelial cells
Differentiated human bronchial epithelial cells in air liquid interface cultures (ALI-PBEC) represent a promising alternative for inhalation studies with rodents as these 3D airway epithelial tissueExpand
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