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Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
The functionality of a distinct type of DNA binding domain is described and allows the design ofDNA binding domains for biotechnology. Expand
Xanthomonas AvrBs3 family-type III effectors: discovery and function.
  • J. Boch, U. Bonas
  • Biology, Medicine
  • Annual review of phytopathology
  • 5 August 2010
The discovery of TAL effectors is described, which act as transcriptional activators in the plant cell nucleus and are determined by a novel modular DNA-binding domain. Expand
TAL effector RVD specificities and efficiencies
The abstracts are presented at the European Society of Gene and Cell Therapy and the British Society for Gene Therapy meeting in Brussels on Tuesday, 2 March to discuss the future of gene therapy and its role in medicine. Expand
Insights into Genome Plasticity and Pathogenicity of the Plant Pathogenic Bacterium Xanthomonas campestris pv. vesicatoria Revealed by the Complete Genome Sequence
ABSTRACT The gram-negative plant-pathogenic bacterium Xanthomonas campestris pv. vesicatoria is the causative agent of bacterial spot disease in pepper and tomato plants, which leads to economicallyExpand
Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors
The data demonstrate that the TALE scaffold can be tailored to target user-defined DNA sequences in whole genomes and mediates specific interaction with G nucleotides that thus far could not be targeted specifically by any known RVD type. Expand
Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72
Genome comparison with the Azoarcus-related soil bacterium strain EbN1 revealed a surprisingly low degree of synteny, indicating a low rate of recent gene transfer that is presumably due to adaptation to a stable, low-stress microenvironment. Expand
Computational Predictions Provide Insights into the Biology of TAL Effector Target Sites
It is demonstrated that TALgetter successfully predicts known TAL effector target sites and often yields a greater number of predictions that are consistent with up-regulation in gene expression microarrays than an existing approach, Target Finder of the TALE-NT suite. Expand
TAL effectors--pathogen strategies and plant resistance engineering.
Recent findings in plant-focused TALE research are summarized and an outline of the newly established gene isolation approach for TALE or RipTAL host target genes with an emphasis on potential pitfalls are provided. Expand
Five phylogenetically close rice SWEET genes confer TAL effector-mediated susceptibility to Xanthomonas oryzae pv. oryzae.
It is predicted and validated that expression of OsSWEET14 is induced by a novel TAL effector, Tal5, from an African Xoo strain, and efficiently complemented an Xoo talC mutant, demonstrating that specific induction of OsC is the key target of TalC. Expand
Osmoregulation in Bacillus subtilis: synthesis of the osmoprotectant glycine betaine from exogenously provided choline
Choline and glycine betaine were not used as sole sources of carbon or nitrogen, consistent with their functional role in the process of adaptation of B. subtilis to high-osmolarity stress. Expand