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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
TLDR
It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene. Expand
Molecular mechanisms of mTOR-mediated translational control
  • X. Ma, J. Blenis
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 May 2009
TLDR
Recent findings on the regulators and effectors of mTOR are highlighted and specific cases that serve as paradigms for the different modes of m TOR regulation and its control of translation are discussed. Expand
ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions
TLDR
The identities of the MK substrates indicate that they play important roles in diverse biological processes, including mRNA translation, cell proliferation and survival, and the nuclear genomic response to mitogens and cellular stresses. Expand
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
TLDR
This approach identifies the tuberous sclerosis complex-2 gene product, tuberin, as a potential target of Akt/PKB, and demonstrates that, upon activation of PI3K, tuber in is phosphorylated on consensus recognition sites forPI3K-dependent S/T kinases. Expand
The RSK family of kinases: emerging roles in cellular signalling
  • R. Anjum, J. Blenis
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 October 2008
TLDR
The current models of RSK signalling are expanded and potential directions of research in RSK-mediated survival, growth, proliferation and migration are highlighted. Expand
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.
TLDR
The Ras-ERK and PI3K-mTOR signaling pathways were originally modeled as linear signaling conduits activated by different stimuli, yet even early experiments hinted that they might intersect to regulate each other and co-regulate downstream functions. Expand
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
TLDR
It is shown that Rheb acts as a novel mediator of the nutrient signaling input to mTOR and is the molecular target of TSC1 and TSC2 within mammalian cells. Expand
Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules
TLDR
Results demonstrate a direct interaction between conventional kinesin and a cargo, indicate that motor proteins are linked to their membranous cargo via scaffolding proteins, and support a role for motor proteins in spatial regulation of signal transduction pathways. Expand
RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation*
TLDR
Evidence is provided that activation of the p90 ribosomal S6 kinases (RSKs) by serum, growth factors, tumor promoting phorbol esters, and oncogenic Ras provides an mTOR-independent pathway linking the Ras/ERK signaling cascade to the translational machinery. Expand
Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated
TLDR
It is demonstrated that distinct Toll-like receptor (TLR) ligands instruct human DCs to induce distinct Th cell responses by differentially modulating mitogen-activated protein kinase signaling. Expand
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