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A Novel Linear Amphipathic β-Sheet Cationic Antimicrobial Peptide with Enhanced Selectivity for Bacterial Lipids*
TLDR
An 18-residue peptide is designed, (KIGAKI)3-NH2, that has no amphipathic character as an α-helix but can form a highly amphipATHic β-sheet when bound to lipids and which was much less effective at inducing leakage in lipid vesicles composed of mixtures of the acidic lipid and neutral lipid.
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Secondary structure and location of a magainin analogue in synthetic phospholipid bilayers.
TLDR
It is demonstrated that the solid-state NMR technique, rotational-echo double resonance (REDOR), can be used to measure both intra- and intermolecular dipole-dipole interactions in membrane-bound peptides.
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Secondary structure and lipid contact of a peptide antibiotic in phospholipid bilayers by REDOR.
The chemical shifts of specific (13)C and (15)N labels distributed throughout KIAGKIA-KIAGKIA-KIAGKIA (K3), an amphiphilic 21-residue antimicrobial peptide, prove that the peptide is in an all…
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Bactericidal activity of magainin 2: use of lipopolysaccharide mutants.
Salmonella typhimurium and a series of rough lipopolysaccharide mutants derived from it were used as target bacteria to examine the antimicrobial capacity of magainin 2. Magainin 2 demonstrated a…
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Interactions between magainin 2 and Salmonella typhimurium outer membranes: effect of lipopolysaccharide structure.
TLDR
The role of the outer membrane and lipopolysaccharide (LPS) in the interaction between the small cationic antimicrobial peptide magainin 2 and the Gram-negative cell envelope was studied by FT-IR spectroscopy, contradicting the proposal by Weiss et al.
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Antioxidants and the mutagenicity of benzo(a) pyrene and some derivatives.
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A new monofluorinated phosphatidylcholine forms interdigitated bilayers.
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Complementary Effects of Host Defense Peptides Piscidin 1 and Piscidin 3 on DNA and Lipid Membranes: Biophysical Insights into Contrasting Biological Activities.
TLDR
Overall, these studies identify two polyreactive piscidin isoforms that bind phosphate-containing targets in a poised amphipathic α-helical conformation, disrupt bacterial membranes, and access the intracellular constituents of target cells.
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Insertion of magainin into the lipid bilayer detected using lipid photolabels.
TLDR
Use of this hydrophobic photolabeling technique has permitted detection of peptide monomers which inserted into the bilayer and/or formed a channel at some time during the labeling procedure.
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Research in the Osteopathic Medical Profession: Roadmap to Recovery
TLDR
The decision to primarily focus research resources on OMM and OPP places the osteopathic medical profession on par with the foci from the DC (doctor of chiropractic)-granted institutions much more so than the MD-granting institutions.
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