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Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
All of the changes in TCA cycle activities correlated with the clinical state (p < 0.01), suggesting a coordinated mitochondrial alteration, and measures to improve T CA cycle metabolism might benefit AD patients. Expand
A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease
Tacrine produced statistically significant, dose-related improvements on objective performance-based tests, clinician- and caregiver-rated global evaluations, and measures of quality of life. Expand
Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain
The activity of the pyruvate dehydrogenase complex (PDHC) was reduced in affected areas of brain from patients with Huntington disease and Alzheimer disease where choline acetyltransferase (CAT) activity was low. Expand
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.
The results suggest that increasing KGDHC via inhibition of TGase or via a host of other strategies to be described would be effective therapeutic approaches in age-associated neurodegenerative diseases. Expand
Instruments for the functional assessment of older patients.
Assessment instruments are particularly useful in screening for problems that often go undetected in older patients and can provide information about conditions and abilities or limitations that are not regularly assessed in standard clinical practice. Expand
Glial glutamate dehydrogenase: Ultrastructural localization and regional distribution in relation to the mitochondrial enzyme, cytochrome oxidase
It is concluded that glial mitochondria are heterogeneous withe respect to their GDH content and that GDH is enriched in areas exhibiting chronically active glutamatergic transmission. Expand