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A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)
TLDR
Comparisons of the behavioral and neuropathological similarities and differences between the icv-STZ mouse and the 3xTg-AD mouse models will help guide future studies using these two mouse models for the development of AD drugs. Expand
Rescue of Synaptic Failure and Alleviation of Learning and Memory Impairments in a Trisomic Mouse Model of Down Syndrome
TLDR
It is shown that peripheral administration of Peptide 6, an 11-mer corresponding to an active region of ciliary neurotrophic factor, can inhibit learning and memory impairments in Ts65Dn mice, a trisomic mouse model of DS. Expand
The carboxy‐terminal fragment of inhibitor‐2 of protein phosphatase‐2A induces Alzheimer disease pathology and cognitive impairment
TLDR
The findings suggest a novel etiopathogenic mechanism of AD, which is initiated by the cleavage of I2PP2A, producing I2CTF, and describe a novel disease‐relevant nontransgenic animal model of AD. Expand
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice
TLDR
Peripheral administration of Peptide 6, an 11-mer, which makes an active region of ciliary neurotrophic factor (CNTF, amino acid residues 146–156), restored cognition by enhancing neurogenesis and neuronal plasticity in these mice. Expand
Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial.
TLDR
Restoration of PP2A activity by inhibition of the cleavage of I(2)(PP2A)/SET offers a promising therapeutic opportunity in AD with this aetiopathogenic mechanism. Expand
Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide
TLDR
Peptide 6, an 11-mer peptide designed based on a biologically active region of the ciliary neurotrophic factor induced proliferation and increased survival and maturation of neural progenitor cells into neurons in the dentate gyrus of normal adult C57BL6 mice. Expand
Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice
TLDR
The design of a peptidergic compound, Ac‐DGGLAG‐NH2, called P21, when administered peripherally, enhanced learning as well as both short‐term and spatial reference memories of normal adult C57Bl6 mice. Expand
Dynamic interplays between memory systems depend on practice: The hippocampus is not always the first to provide solution
TLDR
The findings indicate that learning in one session consists of three acquisition stages with parallel engagement of multiple memory systems at the beginning of learning, and suggest that, in a later phase, dynamic interplays promote the use of the most adapted brain system depending on practice and this is accompanied by specific patterns of CREB phosphorylation in the hippocampus. Expand
Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease
TLDR
It is raised the possibility that EHT may make a substantial contribution to the apparent neuroprotective benefits associated with coffee consumption as evidenced by numerous epidemiologic studies indicating that coffee drinkers have substantially lowered risk of developing AD. Expand
An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide
TLDR
Peripheral administration of Peptide 6 rescued neurodegeneration and cognitive deficit in I2NTF–CTF animals by increasing dentate gyrus neurogenesis and mRNA level of brain derived neurotrophic factor. Expand
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