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Heart valve development: endothelial cell signaling and differentiation.
During the past decade, single gene disruption in mice and large-scale mutagenesis screens in zebrafish have elucidated many fundamental genetic pathways that govern early heart patterning andExpand
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Engineering Robust and Functional Vascular Networks In Vivo With Human Adult and Cord Blood–Derived Progenitor Cells
The success of therapeutic vascularization and tissue engineering will rely on our ability to create vascular networks using human cells that can be obtained readily, can be expanded safely ex vivo,Expand
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In vivo vasculogenic potential of human blood-derived endothelial progenitor cells.
Vascularization of tissues is a major challenge of tissue engineering (TE). We hypothesize that blood-derived endothelial progenitor cells (EPCs) have the required proliferative and vasculogenicExpand
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Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo
Arterial conduits are increasingly preferred for surgical bypass because of inherent functional properties conferred by arterial endothelial cells, especially nitric oxide production in response toExpand
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Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor
Although insulin-like growth factor 1 (IGF-1) has been associated with retinopathy, proof of a direct relationship has been lacking. Here we show that an IGF-1 receptor antagonist suppresses retinalExpand
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Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
Infantile hemangiomas are localized and rapidly growing regions of disorganized angiogenesis. We show that expression of vascular endothelial growth factor receptor-1 (VEGFR1) in hemangiomaExpand
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Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells
Fatty acid binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis. FABP4 has been primarily regarded as an adipocyte‐ and macrophage‐specific protein, butExpand
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Infantile Hemangiomas: Current Knowledge, Future Directions. Proceedings of a Research Workshop on Infantile Hemangiomas
Ilona J. Frieden, M.D.,* Anita N. Haggstrom, M.D.,† Beth A. Drolet, M.D.,‡ Anthony J. Mancini, M.D.,§ Sheila Fallon Friedlander, M.D.,¶ Laurence Boon, M.D., Ph.D.,** Sarah L. Chamlin, M.D.,§ EulaliaExpand
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NFATc1 Mediates Vascular Endothelial Growth Factor-induced Proliferation of Human Pulmonary Valve Endothelial Cells*
Mice deficient for the transcription factor NFATc1 fail to form pulmonary and aortic valves, a defect reminiscent of some types of congenital human heart disease. We examined the mechanisms by whichExpand
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Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice.
Infantile hemangioma is a benign endothelial tumor composed of disorganized blood vessels. It exhibits a unique life cycle of rapid postnatal growth followed by slow regression to a fibrofattyExpand
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