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Src Kinase Activity Is Regulated by the SHP-1 Protein-tyrosine Phosphatase*
It is shown that Src isolated from human platelets and Jurkat T cells is preferentially dephosphorylated at its inhibitory phosphotyrosine site by the SHP-1 tyrosine phosphatase, providing compelling evidence that SHp-1 functions include the positive regulation of Src activation.
Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora.
One new norlignan and five new lignans were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification, and most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 cancer cell lines.
Overexpression of the natural tetrapeptide acetyl‐N‐ser‐asp‐lys‐pro derived from thymosin β4 in neoplastic diseases
These first results strongly suggest a key role for AcSDKP in the pathogenesis of cancer.
Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell
The motheaten mouse provides a powerful model of delineating the precise function of PTP1C and thereby elucidating the specific molecular mechanisms whereby this tyrosine phosphatase participates in the control of hemopoietic cell differentiation and function.
Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages.
The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo.
The tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), purified from bone marrow and constitutively synthesized in vivo, belongs to the family of negative regulators of hematopoiesis. It protects the stem
Antibacterial Labdane Diterpenoids from Vitex vestita.
Vitexolide A exhibited the most potent antibacterial activity with minimal inhibitory concentration values ranging from 6 to 96 μM, whereas compounds 2 and 6-9 showed moderate antib bacterial activity.
Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius.
Seven new prenylated stilbenes, schweinfurthins K-Q (7-13), were isolated, along with vedelianin (1), schwenfurthins E-G, mappain (5, and methyl-mappain), and the structures of the new compounds were established by spectroscopic data analysis.
Reduction-responsive cholesterol-based block copolymer vesicles for drug delivery.
A new robust reduction-responsive polymersome based on the amphiphilic block copolymer PEG-SS-PAChol that could be used as drug carriers with very long circulation profiles and slow release kinetics is developed.