Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
The largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4, achieves genome- wide significance including 18 novel loci, which provide potential new biological mechanisms for bipolar disorder.
Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database
This study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.
SLC6A4 variation and citalopram response
It is suggested that multiple variations in the SLC6A4 gene are associated with remission in white non‐Hispanic depressed adults treated with citalopram, and the mechanism of action of these variants remains to be determined.
Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology
A genome-wide association study of bipolar disorder cases and controls identified 64 associated genomic loci and implicated 15 genes robustly linked to BD via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN.
Machine learning in genome‐wide association studies
Machine learning approaches are promising complements to standard single‐and multi‐SNP analysis methods for understanding the overall genetic architecture of complex human diseases, however, because they are not optimized for genome‐wide SNP data, improved implementations and new variable selection procedures are required.
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
A meta-analysis of genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome revealed a meaningful structure within the eight disorders identifying three groups of inter-related disorders.
Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans
It is concluded that loss of one copy of the POMC gene predisposes to obesity in humans and genetic variants having relatively subtle effects on PomC expression and function could influence susceptibility to obesity.
CYP2C19 variation and citalopram response
- D. Mrazek, J. Biernacka, R. Weinshilboum
- Medicine, PsychologyPharmacogenetics & Genomics
- 1 January 2011
Variations in CYP2C19 were associated with tolerance and remission in a large sample of White non-Hispanic patients treated with citalopram, despite several limitations including the lack of serum drug levels.
Gene set analysis of SNP data: benefits, challenges, and future directions
An overview of Gene set analysis is provided, highlighting the key challenges, potential solutions, and directions for ongoing research.
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
The largest genome-wide association study to date of DSM-IV-diagnosed AD found loci associated with AD and characterized the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.