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Synthesis of a potential reactivator of acetylcholinesterase—1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)propane dibromide
Two methods for the synthesis of a new unsymmetric bispyridinium oxime-1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)propane dibromide are described. In vitro efficacy of this new oxime… Expand
Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.
- K. Kuča, J. Bielavský, J. Cabal, J. Kassa
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 20 October 2003
Synthesis of a new asymmetric bisquaternary reactivator of tabun-inhibited acetylcholinesterase-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide is described.… Expand
Kinetics of inhibition of cholinesterases by 1,2,3,4-tetrahydro-9-aminoacridine in vitro
Kinetic and thermodynamic parameters of reactivation of O-isopropyl-methylphosphonylated rat brain acetylcholinesterase by asymmetric bis-quaternary 4-pyridine aldoximes
Affinity of bis-quaternary pyridinedialdoximes for the active centre of intact and isopropylmethylphophonylated acetylcholinesterase
Protective effect of 1,2,3,4-tetrahydro-9-aminoacridine on acetylcholinesterase inhibition by organophosphorus inhibitors
CHOLINESTERASE REACTIVATORS DERIVED FROM PYRIDINE-2-CARBALDOXIME
Monoquaternary reactivators of cholinesterase 3a-3c were prepared by quaternization of substituted pyridine-2-carbaldoximes with an ester ( 1a , 1b ) or carbamoyl ( 2 ) function in position 4. A new… Expand
Reactivating effect of α,ω‐bis‐(4‐pyridinealdoxime)‐2‐trans‐butene dibromide on isopropyl‐methylphosphonylated acetylcholinesterase
In present work, the preparation of ~,t_d-b&(4_pyri_ dinealdoxime)-Ztrans-butene dibromide and its reactivating ability, with the use of isopropyl-methylphosphonylated bovine erythrocyte acetylcholinesterase (EC 3.1.7), are presented. Expand
3-Nitropropionic acid and similar nitrotoxins.
3-Nitropropionic acid as well as 3-nitro-1-propanol and its beta-D-glucopyranoside (miserotoxin) are the plant and fungal toxins reported to interrupt mitochondrial electron transport resulting in… Expand