Role of Hydrogen Sulfide in the Cardioprotection Caused by Ischemic Preconditioning in the Rat Heart and Cardiac Myocytes
- J. Bian, Q. Yong, P. Moore
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 February 2006
It is suggested that endogenous H2S contributes to cardioprotection induced by IP, which effect may involve protein kinase C and sarcolemmal KATP channels.
Hydrogen sulfide attenuates lipopolysaccharide‐induced inflammation by inhibition of p38 mitogen‐activated protein kinase in microglia
- Li-Fang Hu, P. Wong, P. Moore, J. Bian
- Biology, MedicineJournal of Neurochemistry
- 1 February 2007
H2S produced an anti‐inflammatory effect in LPS‐stimulated microglia and astrocytes, which may be due to inhibition of inducible nitric oxide synthase and p38 MAPK signaling pathways.
Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning.
- Q. Yong, Shiau-Wei Lee, C. S. Foo, Kay Li Neo, Xin Chen, J. Bian
- BiologyAmerican Journal of Physiology. Heart and…
- 25 July 2008
It is concluded that endogenous H2S contributes to IPostC-induced cardioprotection and confers the protective effects against ischemia-reperfusion injury through the activation of Akt, PKC, and eNOS pathways.
Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models
- Li-Fang Hu, Ming Lu, Chi Xin Tiong, G. Dawe, G. Hu, J. Bian
- BiologyAging Cell
- 1 April 2010
It is demonstrated for the first time that H2S may serve as a neuroprotectant to treat and prevent neurotoxin‐induced neurodegeneration via multiple mechanisms including anti‐oxidative stress, anti‐inflammation and metabolic inhibition and therefore has potential therapeutic value for treatment of PD.
Hydrogen sulfide in the mammalian cardiovascular system.
- Yi-hong Liu, Ming Lu, Li-Fang Hu, P. Wong, G. D. Webb, J. Bian
- BiologyAntioxidants and Redox Signaling
- 7 May 2012
This comprehensive review covers in detail the effects of H(2)S on the cardiovascular system, especially in disease situations, and also the various underlying mechanisms.
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways
Investigating the role of extracellular signal regulated kinase (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/Akt in SP-induced cardioprotection found that preconditioning with NaHS for three cycles significantly decreased myocardial infarct size and improved heart contractile function in the isolated rat hearts.
Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes.
- Ting-Ting Pan, Zhan-Ning Feng, Shiau-Wei Lee, P. Moore, J. Bian
- Biology, MedicineJournal of Molecular and Cellular Cardiology
- 2006
Hydrogen Sulfide and Cellular Redox Homeostasis
This review presents an overview of the current understanding of H2S specially focusing on the new understanding and mechanisms of the antioxidant effects of H 2S based on recent reports.
Hydrogen sulfide: A novel signaling molecule in the central nervous system
- Boon Hian Tan, P. Wong, J. Bian
- BiologyNeurochemistry International
- 31 January 2010
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