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Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat

Since non‐noxious stimuli were ineffective in this respect, the term “diffuse noxious inhibitory controls” (DNIC) is proposed, and long lasting post‐effects directly related to the duration of conditioning painful stimulus were observed.
Wolters Kluwer (opens in a new tab)

The spino(trigemino)pontoamygdaloid pathway: electrophysiological evidence for an involvement in pain processes.

Neurons recorded in the parabrachial (PB) area, located in the dorsolateral region of the pons, in the anesthetized rat exhibited a clear capacity to encode thermal stimuli in the noxious range.
PubMed (opens in a new tab)

A limited arthritic model for chronic pain studies in the rat

This limited model of arthritis is proposed as a suitable alternative to the polyarthritic rat for prolonged studies and produces a limited arthritic process in rats, stable over 6 weeks and suitable for behavioural and neurochemical studies of various chronic pain treatment methods.
Wolters Kluwer (opens in a new tab)

The organization of the efferent projections from the pontine parabrachial area to the amygdaloid complex: A phaseolus vulgaris leucoagglutinin (PHA‐L) study in the rat

The organization of the efferent projections from the pontine parabrachial (pPB) area to the amygdala has been studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin…
Wiley (opens in a new tab)

Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non‐convergent neurones, supraspinal involvement and theoretical implications

It is concluded that convergent neurones are specifically inhibited by DNIC, and the “contrast” between the messages from these two pools may well produce a significant pain signalling output from the convergent dorsal horn cells.
Wolters Kluwer (opens in a new tab)

Physiological properties of the lamina I spinoparabrachial neurons in the rat.

The nociceptive properties of the lamina I spino-PB neurons are reflected largely by those of PB neurons that were suggested to be involved in autonomic and emotional/aversive aspects of pain.
PubMed (opens in a new tab)

The parabrachial area: electrophysiological evidence for an involvement in visceral nociceptive processes.

The visceral activated neurons exhibited a clear capacity to encode the colorectal distension in noxious range and were activated by thermal and/or mechanical cutaneous noxious stimuli while only 16% of them were activated only by visceral noxious stimulation.
PubMed (opens in a new tab)

Spinal Substance P Receptor Expression and Internalization in Acute, Short-Term, and Long-Term Inflammatory Pain States

The results suggest that SPR internalization might serve as a marker of the contribution of ongoing primary afferent input in acute and persistent pain states, and suggest that there are unique neurochemical signatures for acute, short-term, and long-term inflammatory pain.
SFN (opens in a new tab)

Nucleus centralis of the amygdala and the globus pallidus ventralis: electrophysiological evidence for an involvement in pain processes.

Neurons recorded with extracellular micropipettes in and around the nucleus centralis of the amygdala (Ce) of anesthetized rats were excited or inhibited exclusively or preferentially by noxious stimuli, and these neurons responded to intense transcutaneous electrical stimulation with one or several components of activation or inhibition.
PubMed (opens in a new tab)

Involvement of the spino-parabrachio -amygdaloid and -hypothalamic pathways in the autonomic and affective emotional aspects of pain.

The electrophysiological properties of neurons recorded in some parts of the pathways and the connections of the three termination sites indicate that these pathways are strongly implicated in autonomic, affective-emotional and emotional-memory aspects of pain.
PubMed (opens in a new tab)
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