• Publications
  • Influence
Late and persistent up-regulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro.
Adhesion molecules play a key role in cellular traffic through vascular endothelium, in particular during the inflammatory response when leukocytes migrate from blood into tissues. Since inflammationExpand
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Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment.
The Stro-1 antigen potentially defines a mesenchymal stem cell (MSC) progenitor subset. We here report on the role of human ex vivo-expanded selected Stro-1(+) or Stro-1(-) MSC subsets on theExpand
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  • Open Access
Application of Autologous Hematopoietic Cell Therapy to a Nonhuman Primate Model of Heterogeneous High-Dose Irradiation
Abstract Bertho, J-M., Prat, M., Frick, J., Demarquay, C., Gaugler, M-H., Dudoignon, N., Clairand, I., Chapel, A., Gorin, N-C., Thierry, D. and Gourmelon, P. Application of Autologous HematopoieticExpand
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Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia
Purpose : To follow plasma Flt3-ligand (FL) concentrations in irradiated animals in order to evaluate it as an indicator of bone marrow damage for the management of accidental radiation-inducedExpand
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A European consensus concerning the medical management of mass radiation exposure was obtained in 2005 during a conference held by the European Group for Blood and Bone Marrow Transplantation, theExpand
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Comparison of autologous cell therapy and granulocyte-colony stimulating factor (G-CSF) injection vs. G-CSF injection alone for the treatment of acute radiation syndrome in a non-human primate model.
PURPOSE To compare the efficacy of autologous cell therapy after irradiation combined with granulocyte-colony stimulating factor (G-CSF) injections with G-CSF treatment alone in a heterogeneous modelExpand
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Phenotypic and immunohistological analyses of the human adult thymus: evidence for an active thymus during adult life.
We analyzed cellular content of thymic samples from 26 human healthy donors, ranging from 1 week postnatal to 49 years old. Our results showed that there was an overall decrease in cellular density,Expand
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New Biological Indicators to Evaluate and Monitor Radiation-Induced Damage: An Accident Case Report
Abstract Bertho, J. M., Roy, L., Souidi, M., Benderitter, M., Gueguen, Y., Lataillade, J. J., Prat, M., Fagot, T., De Revel, T. and Gourmelon, P. New Biological Indicators to Evaluate and MonitorExpand
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  • Open Access
Plasma Flt-3 ligand concentration correlated with radiation-induced bone marrow damage during local fractionated radiotherapy.
PURPOSE To determine whether variations in the plasma Flt-3 ligand (FL) concentration after radiotherapy (RT) may serve as a biomarker for radiation-induced bone marrow damage. METHODS ANDExpand
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Mesenchymal stem cells home to injured tissues when co‐infused with hematopoietic cells to treat a radiation‐induced multi‐organ failure syndrome
Recent studies have suggested that ex vivo expansion of autologous hematopoietic cells could be a therapy of choice for the treatment of bone marrow failure. We investigated the potential of aExpand
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