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Antimalarial compounds isolated from plants used in traditional medicine.
Ethnopharmacological approaches appear to be a promising way to find plant metabolites that could be used as templates for designing new derivatives with improved properties and can play a role in the development of new antimalarial drugs. Expand
Chemical composition, cytotoxicity and in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin.
Evaluating the in vitro antiplasmodial and antitrypanosomal activities of essential oils of four Cymbopogon species used in traditional medicine as well as their cytotoxicity shows that essential oil of Cymboogon genus can be a good source of antitryPanosomal agents. Expand
In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria.
The in vitro antiplasmodial activity of crude extracts of 12 plant species traditionally used in Benin for the treatment of malaria is evaluated in order to validate their use and gives some justifications for the traditional uses of some investigated plants. Expand
In vitro antitrypanosomal and antileishmanial activity of plants used in Benin in traditional medicine and bio-guided fractionation of the most active extract.
The in vitro antitrypanosomal and antileishmanial activity of crude extracts of 10 plant species traditionally used in Benin to treat parasitic infections are evaluated to give some justification for antiparasitic activity of some investigated plants. Expand
Antitrypanosomal compounds from the essential oil and extracts of Keetia leucantha leaves with inhibitor activity on Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase.
Several of its constituents and three triterpenic acids present in the dichloromethane leaves extract showed a higher antitrypanosomal activity on bloodstream forms of Tbb as compared to procyclic forms, namely geranyl acetone, phytol, α-ion one, β-ionone, ursolic acid, oleanolic acid and betulinic acid. Expand
Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C.
Crude acidic water extract, fractions and pure isolated compounds from Acanthospermum hispidum showed promising in vitro antiplasmodial activity, and its weak in vivo antimalarial activity and the in vitro cytotoxicity of pure compounds and enriched extracts containing 1 and 2 indicate that the aerial parts of Acantho-hispidum should be used with caution for malaria treatments. Expand
Natural products published in 2009 from plants traditionally used to treat malaria.
This review covers the compounds with antiplasmodial activity isolated from plants which have been published during 2009 organized according to their phytochemical classes. Expand
In vitro antitrypanosomal and antiplasmodial activities of crude extracts and essential oils of Ocimum gratissimum Linn from Benin and influence of vegetative stage.
Ethanol crude extracts of leaves and seeds of Ocimum gratissimum in full flowering stage can be a good source of antitrypanosomal agents and this is the first report about the relation between the plant part extracted, the vegetative stage of the plant, the antitry panosomal and antiplasmodial activities and the cytotoxicity of essential oils and non-volatile extracts. Expand
Structure–activity relationship study of thiosemicarbazones on an African trypanosome: Trypanosoma brucei brucei
To explore the structure–activity relationships of thiosemicarbazones on African trypanosome: Trypanosoma brucei brucei, a series of thirty-five thiosemicarbazones (1–35) have been synthesized andExpand
Chemical composition and nutritional properties of Terminalia catappa L. oil and kernels from Benin
Abstract This work focuses on the physico-chemical characterization of kernels and oil of Terminalia catappa L. from Benin. The detailed physico-chemical properties are given including theExpand