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Antioxidant properties of hydroxy-flavones.
Evidence is provided that hydroxy-flavones exhibit interesting antioxidant properties expressed either by the capacity to scavenge free radicals or to competitively inhibit xanthine oxidase (for 7-hydroxy-Flavones), which may be drug candidates for treating pathologies related to free radical oxidation.
Antioxidant properties of di-tert-butylhydroxylated flavonoids.
Synthesized flavonoids where one or two di-tert-butylhydroxyphenyl (DBHP) groups replaced catechol moiety at position 2 of the benzopyrane heterocycle proved to be poor DPPH radical scavengers, the activity increasing with the number of DBHP units.
Scavenger and antioxidant properties of ten synthetic flavones.
It is found that the presence of the pyrogallol moiety in the B component of flavones gave rise to radical scavenger activity and that C-6 substituted hydroxyl group may also provide the basis for biological activity.
One-electron oxidation of ergothioneine and analogues investigated by pulse radiolysis: redox reaction involving ergothioneine and vitamin C.
The one-electron oxidation of ergothioneine, a molecule with antioxidant properties which is detected at millimolar concentrations in certain tissues and fluids subject to oxidative stress, is investigated, via pulse radiolysis, to find out whether this co-operative interaction between ergothionine and ascorbate may contribute to essential biological redox protection.
Benzoselenazolinone derivatives designed to be glutathione peroxidase mimetics feature inhibition of cyclooxygenase/5-lipoxygenase pathways and anti-inflammatory activity.
The diselenides were shown to be very potent (up to 3 times the activity of ebselen), whereas the benzoselenazolinones were inactive, thus confirming the hypothesis that glutathione peroxidase mimics have anti-inflammatory properties.
Oxidation of CuII to CuIII, Free Radical Production, and DNA Cleavage by Hydroxy-salen−Copper Complexes. Isomeric Effects Studied by ESR and Electrochemistry
A series of copper complexes of bis(hydroxysalicylidene)ethylenediamine (hydroxy-salens) have been synthesized. The hydroxy group in the ortho, meta, or para position on each salicylidene unit was
DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes.
DNA melting temperature studies indicated that the para complex exhibits the highest affinity for DNA and electron spin resonance measurements suggest that DNA contributes positively to the activation of the semi-quinone system and the production of ligand radical species responsible for subsequent strand scission in the absence of a reducing agent.
4-Mercaptoimidazoles derived from the naturally occurring antioxidant ovothiols 2. Computational and experimental approach of the radical scavenging mechanism
The radical-scavenging mechanism of fourteen 4-mercaptoimidazoles, derived from the natural family of ovothiols, was studied via a QSAR approach, cyclic voltammetry, ESR and NMR spectroscopy and the production of a disulphide compound via thiyl radical formation is proposed.
DNA recognition by two mitoxantrone analogues: Influence of the hydroxyl groups
Footprinting experiments with two anthraquinone derivatives structurally related to mitoxantrone and ametantrone are undertaken to assess the influence of the hydroxyl groups on the DNA recognition process and suggest that they do play a role in the recognition of preferred nucleotide sequences.