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Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in man
TLDR
The effect of administration time was more obvious for the solution as shown by a lower quantitative absorption as well as a delay in time to reach the maximal concentration, compared with the ty1/2 β, which was about 10 hours and the mean MRT value was 11 hours.
Kinetics of allopurinol and its metabolite oxypurinol after oral administration of allopurinol alone or associated with benzbromarone in man. Simultaneous assay of hypoxanthine and xanthine by gas
TLDR
The action of the two agents may be synergistic and not antagonistic, a pharmacological justification for the therapeutic use of this drug association and its role on the blood uric acid lowering action is complex.
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