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Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
Progression to androgen-independent growth of human prostate cancers may be mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date, mutations in the ARExpand
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Androgens induce divergent proliferative responses in human breast cancer cell lines
Although the majority of primary human breast cancers express the androgen receptor (AR), the role of androgens in breast cancer growth and progression is poorly understood. We have investigated theExpand
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Androgen receptor agonist activity of the synthetic progestin, medroxyprogesterone acetate, in human breast cancer cells
Medroxyprogesterone acetate (MPA), which is frequently used as second line hormonal therapy for the treatment of metastatic breast cancer, binds with high affinity to the progesterone receptor (PR).Expand
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Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.
The androgen receptor (AR), a member of the steroid receptor superfamily of nuclear transcription factors, mediates androgen signaling in diverse target tissues. Here we report AR gene mutationsExpand
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Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region.
The homeodomain transcription factor NKX3.1 is a prostate-specific tumour suppressor, expression of which is reduced or undetectable in the majority of metastatic prostate tumours. In the normalExpand
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Vascular endothelial growth factor (VEGF) expression in prostate cancer and benign prostatic hyperplasia.
PURPOSE Vascular endothelial growth factor (VEGF) is a potent inducer of endothelial cell growth and is expressed at elevated levels in several tumor types. In this study immunohistochemicalExpand
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Androgen receptor expression of proliferating basal and luminal cells in adult murine ventral prostate.
Maintenance of the size and differentiated function of the adult prostate is dependent on testicular androgens. In this study, simultaneous androgen receptor (AR) immunohistochemistry andExpand
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Adult rhabdoid renal cell carcinoma.
BACKGROUND Pediatric rhabdoid tumor of the kidney is regarded as a distinct neoplasm, whereas rhabdoid differentiation in adult renal cell carcinoma is usually found in association with conventionalExpand
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Estrogen receptor-negative epithelial cells in mouse mammary gland development and growth.
The mouse mammary gland undergoes rapid proliferation during puberty, then cyclical proliferation and involution during adulthood within a 5-day estrous cycle. Although proliferation of mammaryExpand
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9-Cis retinoic acid inhibits growth of breast cancer cells and down-regulates estrogen receptor RNA and protein.
All-trans retinoic acid (tRA) inhibits growth of estrogen receptor-positive (ER+) breast cancer cells in vitro, and a variety of retinoids inhibit development of breast cancer in animal models. 9-cisExpand
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