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Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.
- R. Phillips, M. Burdick, R. Strieter
- Medicine, BiologyThe Journal of clinical investigation
- 1 August 2004
It is demonstrated that a population of human CD45(+)Col I(+)CXCR4(+) circulating fibrocytes migrates in response to CXCL12 and traffics to the lungs in a murine model of bleomycin-induced pulmonary fibrosis.
CXC chemokines in angiogenesis.
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury.
Increased expression of KC/CXCL1 and MIP-2/C XCL2/3 and their interaction with CXCR2 are important in the pathogeneses of VILI, and in vivo inhibition of CXC chemokine ligand interactions led to a marked reduction in neutrophil sequestration and lung injury.
Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice.
Influenza-infected mice deficient for type I IFN-alpha/beta receptor signaling (Ifnar-/- mice) had improved survival and clearance of secondary Streptococcus pneumoniae infection from the lungs and blood, as compared with similarly infected wild-type animals.
The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases.
- R. Phillips, M. Burdick, M. Lutz, J. Belperio, M. Keane, R. Strieter
- Biology, MedicineAmerican journal of respiratory and critical care…
- 1 June 2003
The administration of specific neutralizing anti-CXCL12 antibodies to severe combined immunodeficient mice expressing human non-small cell lung cancer abrogated organ metastases, without affecting primary tumor-derived angiogenesis, suggest that the CXCL 12-C XCR4 biological axis is involved in regulating the metastasis of non- small cell lung cancers.
Cancer CXC chemokine networks and tumour angiogenesis.
An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome.
- A. Panoskaltsis-Mortari, M. Griese, K. Cooke
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 1 May 2011
Significant research efforts have resulted in a paradigm shift away from identifying noninfectious lung injury after HSCT solely as an idiopathic clinical syndrome and toward understanding IPS as a process involving aspects of both the adaptive and the innate immune response.
Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer1
- M. Keane, J. Belperio, Y. Xue, M. Burdick, R. Strieter
- Biology, ChemistryThe Journal of Immunology
- 1 March 2004
The notion that CXCR2 mediates the angiogenic activity of ELR+ CXC chemokines in a preclinical model of lung cancer is supported.
Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation.