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Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
The IGF2BP family’s role in cancer biology is discussed and how this correlates with their proposed functions during embryogenesis is discussed, which could provide valuable targets in cancer treatment with many of their in vivo roles to be fully elucidated.
The Critical Role of RNA m6A Methylation in Cancer.
Screening for selective and potent RNA methyltransferase, demethylase, or m6A-binding protein inhibitors may lead to compounds suitable for future clinical trials in cancer patients.
TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members
It is demonstrated that TRIM16, devoid of a classical RING domain had auto-polyubiquitination activity and acted as an E3 ubiquitin ligase in vivo and in vitro assays.
Expression of Epstein‐Barr virus nuclear antigen‐1 induces B cell neoplasia in transgenic mice.
It is demonstrated that EBNA‐1 is oncogenic in vivo and suggested that the gene product may play a direct role in the pathogenesis of Burkitt's lymphoma and possibly other EBV‐associated malignancies.
Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.
Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression.
The important roles of lncUSMycN and NonO in regulating N-Myc expression and neuroblastoma oncogenesis are demonstrated and the first evidence that amplification of long noncoding RNA genes can contribute to tumorigenesis is provided.
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.
WDR5 is identified as a key cofactor for N-Myc-regulated transcriptional activation and tumorigenesis and as a novel therapeutic target for MYCN-amplified neuroblastomas.
JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma
JMJD6 is identified as a neuroblastoma tumorigenesis factor, and the combination therapy with the CDK7/super-enhancer inhibitor THZ1 and the histone deacetylase inhibitor panobinostat synergistically reduces JMJD6, E2F2, N- myc, c-Myc expression, induces apoptosis in vitro and leads to neuroblastomas tumor regression in mice, which are significantly reversed by forced JM JD6 over-expression.
Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma
A role for Rho and MRTF signaling and its reversal by pharmacologic inhibition using in vitro and in vivo models of human melanoma growth and metastasis is highlighted and targeting the MRTF transcriptional pathway as a novel approach to melanoma therapeutics is supported.
ATP7A is a novel target of retinoic acid receptor β2 in neuroblastoma cells
Data demonstrates ATP7A expression is regulated by retinoic acid receptor β and it has effects on intracellular copper levels, revealing a link between the anticancer action of retinoids and copper metabolism.