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Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes
Summary A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red… Expand
2′-Fluoropyrimidine RNA-based Aptamers to the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF165)
- J. Ruckman, L. Green, +5 authors N. Janjic
- Biology, Medicine
- The Journal of Biological Chemistry
- 7 August 1998
Vascular endothelial growth factor (VEGF) has been implicated in the pathological induction of new blood vessel growth in a variety of proliferative disorders. Using the SELEX process (systematic… Expand
A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria
Mono-allelic expression of gene families is used by many organisms to mediate phenotypic variation of surface proteins. In the apicomplexan parasite Plasmodium falciparum, responsible for the severe… Expand
Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte.
Erythrocyte invasion by the merozoite is an obligatory stage in Plasmodium parasite infection and essential to malaria disease progression. Attempts to study this process have been hindered by the… Expand
PTEX is an essential nexus for protein export in malaria parasites
During the blood stages of malaria, several hundred parasite-encoded proteins are exported beyond the double-membrane barrier that separates the parasite from the host cell cytosol. These proteins… Expand
The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis
A systematic review and meta-analysis examining the association between anti-merozoite antibody responses and incidence of Plasmodium falciparum malaria by Freya Fowkes and colleagues aids… Expand
Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development
- Michelle J. Boyle, D. Wilson, +6 authors J. Beeson
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 26 July 2010
During blood-stage infection by Plasmodium falciparum, merozoites invade RBCs. Currently there is limited knowledge of cellular and molecular invasion events, and no established assays are available… Expand
Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties.
- J. Beeson, G. Brown, M. Molyneux, C. Mhango, F. Dzinjalamala, S. Rogerson
- Medicine, Biology
- The Journal of infectious diseases
- 1 August 1999
Plasmodium falciparum malaria during pregnancy is an important cause of maternal and infant morbidity and mortality. Accumulation of large numbers of P. falciparum-infected erythrocytes in the… Expand
Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites.
During erythrocyte invasion, Plasmodium falciparum merozoites use multiple receptor-ligand interactions in a series of coordinated events, but current knowledge of these interactions is limited.… Expand
The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1.
- J. Reeder, A. Cowman, +4 authors G. Brown
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 27 April 1999
Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium falciparum in the placenta, but the parasite ligand involved in adhesion has not previously been identified.… Expand