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A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria
It is shown that a var promoter is sufficient for epigenetic silencing and mono-allelic transcription of this virulence gene family, and are fundamental for the understanding of antigenic variation in P. falciparum-mediated virulence and immune evasion.
PTEX is an essential nexus for protein export in malaria parasites
This work shows that through the generation of two parasite lines defective for essential PTEX components, and analysis of a line lacking the non-essential component TRX2, greatly reduced trafficking of all classes of exported proteins beyond the double membrane barrier enveloping the parasite.
Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties.
Agglutination assay results suggest that parasites infecting pregnant women are antigenically distinct from those common in childhood disease and the prevalence of agglutinating antibodies to pregnancy isolates was generally low, but it was highest in multigravidae who are likely to have had the greatest exposure.
The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis
A systematic review and meta-analysis examining the association between anti-merozoite antibody responses and incidence of Plasmodium falciparum malaria by Freya Fowkes and colleagues aids
Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development
It is demonstrated that processing of the major merozoite antigen merozosite surface protein-1 occurs at the time of RBC invasion, which has important implications for defining invasion events and molecular interactions, understanding immune interactions, and identifying and evaluating inhibitors to advance vaccine and drug development.
Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites.
Using real-time imaging of invasion, it is established that heparin-like molecules block early, and essential, events in erythrocyte invasion by merozoites, and it is demonstrated that MSP1-42, a processed form ofmerozoite surface protein 1 (MSP1) involved in invasion, bound heParin in a specific manner.
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand
It is demonstrated that CR1 is an erythrocyte receptor used by the parasite ligand PfRh4 for P. falciparum invasion, and that Parasite invasion via sialic acid–independent pathways is reduced in low-CR1 ERYthrocytes due to limited availability of this receptor on the surface.