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Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium.
There is a lack of suitable animal models that replicate the slowly progressive chronic interstitial fibrosis that is characteristic of many human chronic nephropathies. We describe a chronicExpand
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Freezing tolerance of the New Zealand alpine weta, Hemideina maori hutton [Orthoptera; Stenopelmatidae]
Abstract 1. 1.|The New Zealand weta, Hemideina maori, is shown to withstand freezing, below its supercooling point, for at least 5 h at −9°C and for at least 8 h at −8°C. 2. 2.|The lower lethalExpand
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ORE, a Eukaryotic Minimal Essential Osmotic Response Element
Organisms, almost universally, adapt to hyperosmotic stress through increased accumulation of organic osmolytes but the molecular mechanisms have only begun to be addressed. Among mammalian tissues,Expand
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A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects.
1. A radioimmunoassay has been developed for measuring endothelin-like immunoreactivity in human plasma using an antibody raised against endothelin-1 which also cross-reacts with big endothelin-1 andExpand
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Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride.
BACKGROUND AND OBJECTIVES Polyuria, polydipsia, and nephrogenic diabetes insipidus have been associated with use of psychotropic medications, especially lithium. DESIGN, SETTING, PARTICIPANTS, &Expand
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Aquaporin expression in normal human kidney and in renal disease.
Aquaporins (AQPs), membrane-inserted water channel proteins, play a highly important role in the reabsorption of water from the renal tubular fluid. Experimentally, both in rats and mice, failure toExpand
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Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus.
In lithium-induced nephrogenic diabetes insipidus (NDI), alterations in renal medullary osmolyte concentrations have been assumed but never investigated. Amiloride can modify lithium-induced NDI, butExpand
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Osmoregulation by slow changes in aldose reductase and rapid changes in sorbitol flux.
Renal medullary extracellular NaCl concentration is high during antidiuresis. To compensate, the cells accumulate large amounts of nonperturbing, osmotically active solutes (organic "osmolytes"),Expand
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Response of tissues of the rat to anisosmolality in vivo.
Rats were exposed to osmotic stress either acutely, over periods of 1 or 4 h, or chronically, over several days. In acute experiments, hyposmolality was induced by intraperitoneal infusion of diluteExpand
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Haemolymph composition of two species of new zealand weta, Hemideina (orthoptera; stenopelmatidae)
Abstract 1. 1. Analysis of the haemolymph composition of two species of New Zealand wetas gave the following data. 2. 2. Both species have a typical composition in terms of the inorganic fraction ofExpand
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