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Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Some people who repeatedly use stimulant drugs, such as amphetamine (AMPH), develop an AMPH-induced psychosis that is similar to paranoid schizophrenia. There has been, therefore, considerable… Expand
Gender Differences in Dopaminergic Function in Striatum and Nucleus Accumbens
- J. Becker
- Chemistry, Medicine
- Pharmacology Biochemistry and Behavior
- 1 December 1999
In female rats the gonadal hormones estrogen and progesterone modulate dopamine (DA) activity in the striatum and nucleus accumbens. For example, there is estrous cycle-dependent variation in basal… Expand
Sex differences in drug abuse
Sex differences are present for all of the phases of drug abuse (initiation, escalation of use, addiction, and relapse following abstinence). While there are some differences among specific classes… Expand
Biological Basis of Sex Differences in the Propensity to Self-administer Cocaine
Women are at greater risk for cocaine addiction than are men, and female rats similarly show a greater propensity to self-administer cocaine than do male rats. This could be due to the intrinsic sex… Expand
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.
The lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA) and other components of the mesolimbic dopamine (DA) system to control motivation, including the incentive to… Expand
Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
In this review we propose that there are sex differences in how men and women enter onto the path that can lead to addiction. Males are more likely than females to engage in risky behaviors that… Expand
Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats
Men and women differ in their response to cocaine, and a woman's response varies with the menstrual cycle. For example, women have greater subjective responses to cocaine in the follicular phase of… Expand
Strategies and methods for research on sex differences in brain and behavior.
Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although… Expand
Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.
- G. Leinninger, Darren M. Opland, +10 authors M. Myers
- Biology, Medicine
- Cell metabolism
- 7 September 2011
Leptin acts on leptin receptor (LepRb)-expressing neurons throughout the brain, but the roles for many populations of LepRb neurons in modulating energy balance and behavior remain unclear. We found… Expand
Effects of Sex and Estrogen on Behavioral Sensitization to Cocaine in Rats
Estrogen rapidly enhances dopamine (DA) activity in the striatum and nucleus accumbens as well as behavioral responses to psychomotor stimulants in female rats but not males. This experiment was… Expand