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A clinical trial for advanced cervico-vaginal pelvic carcinomas using Californium Cf-252 fast neutron therapy: report of early responses.
TLDR
Clinical experiences with Californium (Cf) 252 for the radiotherapy of advanced cervicovaginal carcinomas at the University of Kentucky Medical Center from November 1976 to April 1979 are summarized. Expand
NEUTRON BRACHYTHERAPY IS BETTER THAN CONVENTIONAL RADIOTHERAPY IN ADVANCED CERVICAL CANCER
TLDR
Californium-252 (252Cf), a fast-neutron emitting radioisotope, was used for neutron brachytherapy of 82 patients with advanced cervical cancer, and in patients with stage IIIB disease, intracavitary therapy resulted in 54% 5-year survival compared with 12% in the caesium group. Expand
Boron neutron capture enhancement of 252Cf brachytherapy.
TLDR
It is concluded that there is a sufficiently high thermal neutron fluence present during californium brachytherapy for boron neutron capture dose augmentation to be feasible. Expand
X-ray beam characteristics of the Varian Clinac 6-100 linear accelerator.
TLDR
Investigation of surface dose and depth of maximum dose reveal a dependence on field size, and treatment planning parameters including field size output factors and wedge factors are discussed. Expand
Scheduling of hypoxic-tumor therapy using neutron brachytherapy.
TLDR
Findings indicate that traditional concepts developed for the use of conventional low-LET therapy may need to be altered to use neutrons for therapy and to achieve improved local control of advanced cancers. Expand
RBE of spleen CFU-S to low dose rate Cf-252 or photon radiation in vivo.
TLDR
The biological effects of low dose rate (LDR) Cf-252 radiation were compared to LDR Cs-137 photon radiation and acute 60Co radiation and showed greater growth delay for Cf- 252 irradiated lympho-hemopoietic tissues. Expand
A tumor/normal tissue advantage for low dose rate neutron brachytherapy.
TLDR
Cf-252 brachytherapy increases the dose differential, therapeutic gain and the probability of local tumor control, since the high RBE of Cf-252 for hypoxic tumor is much less in normal tissues. Expand
RBE of CF-252 neutrons by mouse testes weight loss.
TLDR
Mouse testes weight decreased with increasing radiation dose following exposure to Cf-252 and its mixed neutron plus gamma radiation, and the RBE was calculated against acute 60Co and Cs-137. Expand
RBE of spleen CFU-S to low dose rate Cf-252 neutron or photon radiation
TLDR
The RBE of Cf-252 neutron irradiation was determined for hemopoietic tissue using spleen CFU-S using identical irradiation conditions to assess Radiosensitivity and no dose rate effect was observed for hemobiology to acute doses or low dose rate photon irradiation. Expand
A comparison of air-cavity inhomogeneity effects for cobalt-60, 6-, and 10-MV x-ray beams.
TLDR
The magnitude and spatial extent of underdosing and overdosing at the distal surface for two linear accelerators (10- and 6-MV x-rays) and a cobalt-60 machine and a small buildup/extrapolation chamber is compared. Expand
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