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B Lymphocytes Producing Demyelinating Autoantibodies: Development and Function in Gene-targeted Transgenic Mice
Oxidative damage in multiple sclerosis lesions
The data suggest profound oxidative injury of oligodendrocytes and neurons to be associated with active demyelination and axonal or neuronal injury in multiple sclerosis.
Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo
A diagnostic hallmark of this disease is the presence of serum autoantibodies against the water channel aquaporin‐4 (AQP‐4) on astrocytes.
Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis.
Findings strongly support a central role for T cell-mediated neuronal cytotoxicity in encephalitides with antibodies against intracellular antigens in voltage-gated potassium channel-complex encephalitis.
Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances
Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?
- Christina Marik, P. Felts, J. Bauer, H. Lassmann, Kenneth J. Smith
- Biology, PsychologyBrain : a journal of neurology
- 1 November 2007
It is suggested that the areas of microglial activation represent an early stage of tissue injury, which precedes the formation of hypoxia-like demyelinated plaques in MS.
Widespread Demyelination in the Cerebellar Cortex in Multiple Sclerosis
It is described that the cerebellar cortex is a major predilection site for demyelination, in particular in patients with primary and secondary progressive MS, and is identified as a potential substrate of Cerebellar dysfunction in MS.
T‐ and B‐cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis
- A. Iglesias, J. Bauer, T. Litzenburger, A. Schubart, C. Linington
- Biology, MedicineGlia
- 1 November 2001
Current understanding of MOG as a target autoantigen in EAE and MS is provided, and the crucial question as to how immune tolerance to MOG may be maintained in the healthy individual is addressed.
Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitis
Findings indicate that a T‐cell–mediated cytotoxic reaction induces neuronal death in Rasmussen's encephalitis, and shows, for what is believed to be the first time, that a cytot toxic T‐ cell mechanism contributes to loss of neurons in human brain disease.