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B Lymphocytes Producing Demyelinating Autoantibodies: Development and Function in Gene-targeted Transgenic Mice
We studied the cellular basis of self tolerance of B cells specific for brain autoantigens using transgenic mice engineered to produce high titers of autoantibodies against the myelin oligodendrocyteExpand
Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo
A diagnostic hallmark of this disease is the presence of serum autoantibodies against the water channel aquaporin‐4 (AQP‐4) on astrocytes. Expand
Oxidative damage in multiple sclerosis lesions
The data suggest profound oxidative injury of oligodendrocytes and neurons to be associated with active demyelination and axonal or neuronal injury in multiple sclerosis. Expand
Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis.
Findings strongly support a central role for T cell-mediated neuronal cytotoxicity in encephalitides with antibodies against intracellular antigens in voltage-gated potassium channel-complex encephalitis. Expand
Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
In MS, damage of axons is closely linked to the CD8(+) CTLs, and protection against CTL-mediated damage should be considered as a new therapeutic approach in MS and other neuroinflammatory diseases. Expand
Widespread Demyelination in the Cerebellar Cortex in Multiple Sclerosis
It is described that the cerebellar cortex is a major predilection site for demyelination, in particular in patients with primary and secondary progressive MS, and is identified as a potential substrate of Cerebellar dysfunction in MS. Expand
Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances
Neuropathological and immunological studies support the notion that Rasmussen's encephalitis is probably driven by a T-cell response to one or more antigenic epitopes, with potential additional contribution by autoantibodies. Expand
Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary
It is demonstrated that aberrant local TNF/p55TNF receptor signaling in the central nervous system can have a potentially major role in the aetiopathogenesis of MS demyelination, particularly in MS subtypes in which oligodendrocyte death is a primary pathological feature. Expand
Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitis
Findings indicate that a T‐cell–mediated cytotoxic reaction induces neuronal death in Rasmussen's encephalitis, and shows, for what is believed to be the first time, that a cytot toxic T‐ cell mechanism contributes to loss of neurons in human brain disease. Expand
The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
It is shown that fibrinogen, which is deposited perivascularly in MS plaques, signals through Mac-1 and induces the differentiation of microglia to phagocytes via activation of Akt and Rho and could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglian activation. Expand