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Basic methods in molecular biology
General methods bacterial strains and cloning vectors enzymes that modify DNA and RNA in vitro amplification of DNA using - the polymerase chain reaction (PCR) and the thermostable Taq DNAExpand
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Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function
Positional cloning of hereditary deafness genes is a direct approach to identify molecules and mechanisms underlying auditory function. Here we report a locus for dominant deafness, DFNA36, whichExpand
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Putative Mammalian Taste Receptors A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity
Taste represents a major form of sensory input in the animal kingdom. In mammals, taste perception begins with the recognition of tastant molecules by unknown membrane receptors localized on theExpand
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Identification of a Signaling Network in Lateral Nucleus of Amygdala Important for Inhibiting Memory Specifically Related to Learned Fear
We identified the Grp gene, encoding gastrin-releasing peptide, as being highly expressed both in the lateral nucleus of the amygdala, the nucleus where associations for Pavlovian learned fear areExpand
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International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB1), the gastrin-releasing peptide (GRP) receptor (BB2), and theExpand
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The Knockout Mouse Project
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling forExpand
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BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.
The bombesin (BN)-like peptides mediate a diverse spectrum of biological activities and have been implicated as autocrine growth factors in the pathogenesis and progression of some human small cellExpand
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Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.
Bombesin-like peptides have been implicated as autocrine growth factors influencing the pathogenesis and progression of some human lung carcinoma cells. To determine the pharmacologic and structuralExpand
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Identification of a novel member of the T1R family of putative taste receptors
In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of GExpand
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L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer
Altered structure and regulation of the c-myc proto-oncogene have been associated with a variety of human tumours and derivative cell lines, including Burkitt's lymphoma1,2, promyelocyticExpand
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