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Investigation of DMSO-induced conformational transitions in human serum albumin using two-dimensional raman optical activity spectroscopy.
Recent Raman and Raman optical activity (ROA) results have demonstrated that dimethyl sulfoxide (DMSO) induces the selective conversion of α-helix motifs into the poly(L-proline) II (PPII) helixExpand
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VCD to determine absolute configuration of natural product molecules: secolignans from Peperomia blanda.
The absolute configuration and solution-state conformers of three peperomin-type secolignans isolated from Peperomia blanda (Piperaceae) are unambiguously determined by using vibrational circularExpand
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Determination of catechin diastereomers from the leaves of Byrsonima species using chiral HPLC-PAD-CD.
When catechins are found in plant extracts, they are almost always identified as catechin and/or epicatechin probably due to stereoselectivity of the enzymes involved in the biosynthesis of theseExpand
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Recent advances in the use of vibrational chiroptical spectroscopic methods for stereochemical characterization of natural products.
This review covers conformational and configurational assignments in natural product molecules using chiroptical spectroscopy reported over the last 15 years. Special attention is given toExpand
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Absolute configuration reassignment of two chromanes from Peperomia obtusifolia (Piperaceae) using VCD and DFT calculations
Abstract Previous analysis of the ECD spectra of two prenylated benzopyrans isolated from Peperomia obtusifolia, by means of the helicity rule for the chromane chromophore, resulted in the incorrectExpand
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Absolute configuration and selective trypanocidal activity of gaudichaudianic acid enantiomers.
Gaudichaudianic acid, a prenylated chromene isolated from Piper gaudichaudianum, has been described as a potent trypanocidal compound against the Y-strain of Trypanosoma cruzi. We herein describe itsExpand
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Natural chromenes and chromene derivatives as potential anti-trypanosomal agents.
The aim of the study was to investigate the anti-trypanocidal activities of natural chromene and chromene derivatives. Five chromenes were isolated from Piper gaudichaudianum and P. aduncum, and aExpand
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Selective DMSO-induced conformational changes in proteins from Raman optical activity.
The function of a protein is determined by its structure, which is intrinsically related to its solvent environment. Based on this paradigm, there has been a great deal of interest in the role thatExpand
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Structure elucidation and absolute stereochemistry of isomeric monoterpene chromane esters.
Six novel monoterpene chromane esters were isolated from the aerial parts of Peperomia obtusifolia (Piperaceae) using chiral chromatography. This is the first time that chiral chromane esters of thisExpand
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Albendazole sulfoxide enantiomers: preparative chiral separation and absolute stereochemistry.
The enantiomeric separation of albendazole sulfoxide was carried out by simulated moving bed chromatography with variable zones (VARICOL). An overall recovery of 97% was achieved and enantiomericExpand
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