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EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt.
TLDR
In human astrocytoma, S897 phosphorylation was correlated with tumor grades and Akt activation, suggesting that the Akt-EphA2 crosstalk may contribute to brain tumor progression. Expand
In vivo magnetic resonance imaging of transgene expression
Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.
TLDR
Site‐directed mutagenesis demonstrates that the sequence surrounding the mapped endonuclease cleavage site is required for both iron‐regulated mRNA turnover and generation of the truncated degradation intermediate of the transferrin receptor mRNA. Expand
Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins.
TLDR
A superposition of refined structures indicates that the conserved C in the internal bulge, and three residues in the six-nucleotide hairpin loop are quite dynamic in this RNA. Expand
Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.
TLDR
Site-directed mutagenesis of IRP1 and IRP2 reveals that, although the binding affinities for consensus IREs are indistinguishable, the contributions of arginine residues in the active-site cleft to the binding affinity are different in the two RNA binding sites. Expand
Deep penetration of a PDT drug into tumors by noncovalent drug-gold nanoparticle conjugates.
TLDR
It is suggested that noncovalent delivery via Au NPs provides an attractive approach for cancer drugs to penetrate deep into the center of tumors. Expand
Human transferrin receptor gene as a marker gene for MR imaging.
TLDR
ETR+ tumors internalize the MR imaging probe through the action of transferrin receptor in amounts that can be detected with MR imaging, and findings were consistent with accumulation by the receptor-mediated endocytosis mechanism of ETR. Expand
Peptide-Targeted Gold Nanoparticles for Photodynamic Therapy of Brain Cancer.
TLDR
In vivo and in vivo data demonstrate that EGFpep-Au NP-Pc 4 utilizes cancer-specific biomarkers to improve drug delivery and therapeutic efficacy over untargeted drug delivery. Expand
Development of Targeted Near-Infrared Imaging Agents for Prostate Cancer
TLDR
The results indicated that PSMA-targeted probes have the potential to be further developed as contrast agents for clinical intraoperative fluorescence-guided surgery and the pharmacokinetics of the probes was dependent of the fluorophore conjugated to thePSMA-1 ligand and varied widely. Expand
Single-nucleotide polymorphisms can cause different structural folds of mRNA.
TLDR
The observation of marked differences in mRNA secondary structure associated with SNPs in the coding regions of two human mRNAs is reported, and it is found that the SNP exerts an allele-specific effect on the accessibility of its flanking site in the endogenous human RPA70 mRNA. Expand
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