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Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Bacterial infection remains a serious threat to human lives because of emerging resistance to existing antibiotics. Although the scientific community has avidly pursued the discovery of newExpand
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Identification of CDK4 as a target of c-MYC.
The prototypic oncogene c-MYC encodes a transcription factor that can drive proliferation by promoting cell-cycle reentry. However, the mechanisms through which c-MYC achieves these effects have beenExpand
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Participation of cyclin A in Myc-induced apoptosis.
The involvement of c-Myc in cellular proliferation or apoptosis has been linked to differential cyclin gene expression. We observed that in both proliferating cells and cells undergoing apoptosis,Expand
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Empirical antibacterial drug discovery--foundation in natural products.
Natural products have been a rich source in providing leads for the development of drugs for the treatment of bacterial infections. However, beyond the discovery of the natural product, thienamycinExpand
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A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain.
The c-Myc protein is a transcription factor with an N-terminal transcriptional regulatory domain and C-terminal oligomerization and DNA-binding motifs. Previous studies have demonstrated that p107, aExpand
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Antibiotics: where did we go wrong?
In the late 1960s, the medical need for new antibiotics began to be questioned, and the pharmaceutical industry shifted its emphasis of antibacterials from that of a therapeutic leader to aExpand
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An expansion for some second-order probability distributions and its application to noise problems
In this paper it is shown that, in general, second-order probability distributions may be expanded in a certain double series involving orthogonal polynomials associated with the corresponding first-order distributions. Expand
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A Novel c-Myc-responsive Gene, JPO1, Participates in Neoplastic Transformation*
We have identified a novel c-Myc-responsive gene, named JPO1, by representational difference analysis.JPO1 responds to two inducible c-Myc systems and behaves as a direct c-Myc target gene. JPO1 mRNAExpand
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Arsenic inhibition of telomerase transcription leads to genetic instability.
Arsenic is effective in the treatment of acute promyelocytic leukemia. Paradoxically, it is also carcinogenic. In the process of elucidating a mechanism of arsenic resistance in a leukemia cell line,Expand
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Transformation of Streptococcus mutans with chromosomal and shuttle plasmid (pYA629) DNAs.
Transformation (i.e., DNase-sensitive genetic transfer) of strains of Streptococcus mutans representing serotypes c and e was accomplished by using chromosomal DNA from a Rifr Strr Spcr isolate ofExpand
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