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Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy.
Adenosine levels increase at seizure foci as part of a postulated endogenous negative feedback mechanism that controls seizure activity through activation of A1 adenosine receptors. Agents thatExpand
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Extracellular nucleotide catabolism in human B and T lymphocytes. The source of adenosine production.
Extracellular nucleotide degradation was studied in intact human B and T lymphocyte subpopulations and in lymphoblastoid cell lines. Cells of B lymphocyte lineage showed high nucleotide degradingExpand
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Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins.
Adenosine and adenosine analogues exhibit anti-inflammatory effects in vitro and in vivo, but their usefulness is limited by profound cardiovascular side effects. Therefore, we synthesized inhibitorsExpand
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Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors.
The physiological role of adenosine (Ado) is well known. Although a number of pharmacological attempts have been made to manipulate Ado concentrations in ischemic conditions in different tissues,Expand
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Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism.
Purine and pyrimidine deoxyribonucleoside metabolism was studied in G1 and S phase human thymocytes and compared with that of the more mature T lymphocytes from peripheral blood. Both thymocyteExpand
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Evidence for active purine nucleoside cycles in human mononuclear cells and cultured fibroblasts.
Several aspects of purine metabolism were studied in peripheral blood mononuclear cells and fibroblasts from a patient with purine nucleoside phosphorylase deficiency and compared to cells fromExpand
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Establishment and characterization of adenosine deaminase-deficient human T cell lines.
We have established long term cell lines from a patient with adenosine deaminase (ADA)-deficient severe combined immunodeficiency by stimulation of blood and bone marrow cells with PHA and IL-2Expand
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Purine nucleotide metabolism in phytohemagglutinin-induced human T lymphocytes.
The comprehensive studies of purine nucleotide metabolism were done in nonstimulated and phytohemagglutinin (PHA)-stimulated human peripheral blood T lymphocytes. Nonstimulated lymphocytes synthesizeExpand
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Metabolic consequences of DNA damage: alteration in purine metabolism following poly(ADP ribosyl)ation in human T-lymphoblasts.
The effect of DNA damage caused by N-methyl-N'-nitro-nitrosoguanidine (MNNG) on poly(ADP-ribose) synthesis, NAD levels, and purine nucleotide metabolism was studied in human T-lymphoblasts. ExcessiveExpand
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Purine salvage in cotyledons of germinating lupin seeds
Purine metabolism is much less elucidated in plants [ 1,2] than in animal tissues. In contrast to animal tissues, in plants adenosine is hydrolyzed to adenine and ribose by adenosine nucleosidase (ECExpand
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