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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning
Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms associated withExpand
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Regulation of Eukaryotic Initiation Factor 4E by Converging Signaling Pathways during Metabotropic Glutamate Receptor-Dependent Long-Term Depression
Long-term depression (LTD) is an activity-dependent decrease in synaptic efficacy that can be induced in hippocampal area CA1 by pharmacological application of the selective group I metabotropicExpand
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Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density.
Apolipoprotein receptors belong to an evolutionarily conserved surface receptor family that has intimate roles in the modulation of synaptic plasticity and is necessary for properExpand
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The Translation Repressor 4E-BP2 Is Critical for eIF4F Complex Formation, Synaptic Plasticity, and Memory in the Hippocampus
Long-lasting synaptic plasticity and memory requires mRNA translation, yet little is known as to how this process is regulated. To explore the role that the translation repressor 4E-BP2 plays inExpand
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Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse
The lipoprotein receptor ligand Reelin is important for the processes of normal synaptic plasticity, dendritic morphogenesis, and learning and memory. Heterozygous reeler mice (HRM) show manyExpand
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ERK and mTOR Signaling Couple β-Adrenergic Receptors to Translation Initiation Machinery to Gate Induction of Protein Synthesis-dependent Long-term Potentiation*
β-Adrenergic receptors critically modulate long-lasting synaptic plasticity and long-term memory in the mammalian hippocampus. Persistent long-term potentiation of synaptic strength requires proteinExpand
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Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus.
cAMP is a critical second messenger implicated in synaptic plasticity and memory in the mammalian brain. Substantial evidence links increases in intracellular cAMP to activation of cAMP-dependentExpand
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Synaptic plasticity and translation initiation.
It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to controlExpand
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Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated
Group III metabotropic glutamate receptors (mGluRs) reduce synaptic transmission at the Schaffer collateral-CA1 (SC-CA1) synapse in rats by a presynaptic mechanism. Previous studies show that lowExpand
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NMDA receptor activation results in PKA‐ and ERK‐dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1
Protein synthesis is essential for the stabilization of glutamate receptor‐dependent forms of long‐lasting hippocampal synaptic plasticity and for the consolidation of memory, but the signalExpand
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