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Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points.
This work shows that in zebrafish embryos there are two distinct phases during LR patterning in which BMP signaling is required, and identifies Bmp4 as the ligand responsible for both phases. Expand
Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart
The data support a model in which modified regulation of these distinct phases of cardiomyocyte differentiation has been responsible for the changes in heart size and morphology among vertebrate species. Expand
Early Endocardial Morphogenesis Requires Scl/Tal1
Early separation of the two components of the primitive heart tube is suggested and Scl/Tal1 is implied as an indispensable component of the molecular hierarchy that controls endocardium morphogenesis. Expand
Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm.
Zebrafish DeltaNp63, encoding an isoform of the p53-related protein p63, is identified as an ectoderm-specific direct transcriptional target of Bmp signaling, and fulfills the criteria to be the neural repressor postulated by the "neural default model". Expand
Zebrafish as a model to study cardiac development and human cardiac disease
  • J. Bakkers
  • Biology, Medicine
  • Cardiovascular research
  • 19 May 2011
In this review, recent discoveries in the field of cardiac development are discussed and specific cases in which the zebrafish has been used to model human congenital and acquired cardiac diseases are discussed. Expand
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
It is demonstrated here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL 9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-Caten in-dependent transcription. Expand
Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells ofExpand
Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis
Surprisingly, inhibition of eNOS prevents Ubiad1-dependent cardiovascular oxidative damage, suggesting a crucial role for this enzyme and nonmitochondrial CoQ10 in NO signaling. Expand
A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.
It is found that Nodal signalling regulates actin gene expression, supporting a model in which NodAl signalling amplifies this tissue-intrinsic mechanism of heart looping, as explanted hearts maintain ex vivo retain chiral looping behaviour and require actin polymerization and myosin II activity. Expand
Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model
The results show that the zebrafish is a useful in vivo animal model for rapid analysis of invasion and metastatic behaviour of primary human tumour specimen. Expand