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Irreversible binding and toxicity of the herbicide dichlobenil (2,6-dichlorobenzonitrile) in the olfactory mucosa of mice.
Metabolism of atrazine and 2-hydroxyatrazine by the rat.
Metabolism of cyclophosphamide by sheep.
Metabolism of 2,4',5-trichlorobiphenyl by the mercapturic acid pathway.
Carbon-14-labeled 2,4',5-trichlorobiphenyl was found to be metabolized by the mercapturic acid pathway to metabolites that are excreted in bile. About 57 percent of the carbon-14 was excreted in the…
Metabolism of 1,2,4-trichlorobenzene in rats: examination of thiol formation.
- J. Bakke, J. Huwe, D. J. Mulford, A. Bergman
- Biology, ChemistryXenobiotica; the fate of foreign compounds in…
Trichlorothiophenols were deduced not to be intermediates or end-products of enzymic metabolism of trichlorobenzene in rats because 14C-2,4,5-trichlorothsiophenol dosed i.p. to rats was excreted as the S-glucuronide and as S-(methylsulphonyl-dichlorophenyl)-mercapturic acid.
Characterization of the major sheep urinary metabolites of cyclophosphamide, a defleecing chemical.
Rat urinary metabolites from O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothioate.
Rats metabolized single oral doses of O,O-diethyl-O(3,5,6-trichloro-2-pyridyl-2,6-14C) phosphorothioate to at least six radiolabeled urinary metabolites. The urine contained about 90 percent of the…
Recent Advances in the Isolation and Identification of Glucuronide Conjugates
- J. Bakke
- 1 June 1976
Mass and infrared spectra of diaryl and aryl alkyl sulfate diesters.
The synthesis and the infrared and mass spectra of diaryl and aryl alkyl sulfate diesters and their infrared spectra gave information useful for characterizing and differentiating these two classes of compounds.
Catabolism of premercapturic acid pathway metabolites of naphthalene to naphthols and methylthio-containing metabolites in rats.
- J. Bakke, C. Struble, J. Gustafsson, B. Gustafsson
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 1 February 1985
The discovery of the essential role of the intestinal microflora in the formation of naphthols from naphthalene indicates the existence of a novel pathway for hydroxylation of aromatic systems and challenges the current concept of the in vivo relevance ofThe in vitro production of n Aphthalene 1,2-oxide.