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Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity
The glycosylation pattern of chCE7, an antineuroblastoma chimeric IgG1, was engineered in Chinese hamster ovary cells with tetracycline–regulated expression of β(1,4)–N–acetylglucosaminyltransferaseExpand
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Toward a science of metabolic engineering
  • J. Bailey
  • Biology, Medicine
  • Science
  • 21 June 1991
Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates. Recruitment ofExpand
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Mechanical properties of ceramics
Mechanical Behaviour of Ceramics.By R. W. Davidge. Pp. 165. (Cambridge University Press: Cambridge, 1979.) £15.
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Metabolic flux responses to pyruvate kinase knockout in Escherichia coli.
The intracellular carbon flux distribution in wild-type and pyruvate kinase-deficient Escherichia coli was estimated using biosynthetically directed fractional 13C labeling experiments withExpand
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Metabolic flux ratio analysis of genetic and environmental modulations of Escherichia coli central carbon metabolism.
The response of Escherichia coli central carbon metabolism to genetic and environmental manipulation has been studied by use of a recently developed methodology for metabolic flux ratio (METAFoR)Expand
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Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells.
Proliferation of mammalian cells can be controlled by low cultivation temperature. However, depending on cell type and expression system, varying effects of a temperature shift on heterologousExpand
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A mathematical model of caspase function in apoptosis
Caspases (cysteine-containing aspartate-specific proteases) are at the core of the cell's suicide machinery. These enzymes, once activated, dismantle the cell by selectively cleaving key proteinsExpand
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Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis.
Continuous cultivation in a glucose-limited chemostat was used to determine the growth parameters of wild-type Bacillus subtilis and of a recombinant, riboflavin-producing strain. MaintenanceExpand
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A higher-than-predicted measurement of iron opacity at solar interior temperatures
Nearly a century ago it was recognized that radiation absorption by stellar matter controls the internal temperature profiles within stars. Laboratory opacity measurements, however, have never beenExpand
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Streptogramin-based gene regulation systems for mammalian cells
Here we describe repressible (PipOFF) as well as inducible (PipON) systems for regulated gene expression in mammalian cells, based on the repressor Pip (pristinamycin-induced protein), which isExpand
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