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Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
It is concluded that the BBB removes Ass from the brain largely via age-dependent, LRP-1-mediated transport that is influenced by alpha(2)M and/or apoE, and may be impaired in AD.
Imaging of Cell Proliferation: Status and Prospects
The most promising use for thymidine and its analogs is in monitoring tumor treatment response, as demonstrated in animal studies and pilot human trials.
Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma
These findings provide promising first-in-human clinical experience for intracranial administration of IL13Rα2-specific CAR T cells for the treatment of GBM, establishing a foundation on which future refinements of adoptive CAR T-cell therapies can be applied.
Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging.
A framework for fully 3D bioluminescence tomographic image acquisition and reconstruction that exploits spectral information is described and regularized tomographic reconstruction techniques that use semi-infinite slab or FEM-based diffusion approximations of photon transport through turbid media are described.
microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts.
PET imaging of (64)Cu-DOTA-[Lys(3)]BBN is able to detect GRPR-positive prostate cancer and shows strong tumor-to-background contrast, as demonstrated in athymic nude mice bearing subcutaneous PC-3 and CWR22 tumors.
MicroPET and autoradiographic imaging of breast cancer alpha v-integrin expression using 18F- and 64Cu-labeled RGD peptide.
Overall molecular charge and characteristics of Radiolabels have profound effects on tumor accumulation and in vivo kinetics of radiolabeled RGD peptide.
Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice.
It is shown that combined activation of the Wnt pathway and attenuation of the transforming growth factor-beta (TGF-beta) pathway causes high multiplicity and rapid onset of invasive tumorigenesis almost exclusively in the distal colon, closely mimicking the familial adenomatous polyposis (FAP) disease and consisting with distinct colorectal cancer etiologies based on tumor location.
Tumor Quantification in Clinical Positron Emission Tomography
The current status of tumor quantification methods and their applications to clinical oncology are reviewed, and factors that impede quantitative assessment and limit its accuracy and reproducibility are summarized.
PET and [18F]-FDG in oncology: a clinical update.
Positron emission tomography (PET) has become a very useful adjunct to anatomic imaging techniques, adding unique information to the characterization of disease. The whole-body PET FDG technique
Perfusion of colorectal hepatic metastases. Relative distribution of flow from the hepatic artery and portal vein
The high extraction efficiency demonstrates that the hepatic artery flow is nutritive, and the delivery of substance in solution to tumor and liver tissue correlates with the distribution of colloids such as macroaggregated albumin after hepatic arterial and portal venous injection.