Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS
- W. Rice, J. Supko, L. Henderson
- Biology, ChemistryScience
- 17 November 1995
Nontoxic disulfide-substituted benzamides were identified that attack the zinc fingers, inactivate cell-free virions, inhibit acute and chronic infections, and exhibit broad antiretroviral activity.
Oxathiin carboxanilide, a potent inhibitor of human immunodeficiency virus reproduction.
- J. Bader, J. Mcmahon, M. Boyd
- BiologyProceedings of the National Academy of Sciences…
- 1 August 1991
The highly active OC has a reversible effect on some early stage of HIV-1 reproduction and cytopathicity, and represents a new class of anti-HIV agents that are promising candidates for drug development.
Unique Anti-Human Immunodeficiency Virus Activities of the Nonnucleoside Reverse Transcriptase Inhibitors Calanolide A, Costatolide, and Dihydrocostatolide
- R. Buckheit, E. White, J. Bader
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 1 August 1999
Comparison of cross-resistance data obtained with a panel of NNRTI-resistant virus strains suggests that a compound of the calanolide A series, such as costatolide, should be evaluated further for therapeutic use in combination with other anti-HIV agents.
3-Deazaadenosine, an inhibitor of adenosylhomocysteine hydrolase, inhibits reproduction of Rous sarcoma virus and transformation of chick embryo cells.
- J. Bader, N. R. Brown, P. Chiang, G. Cantoni
- BiologyVirology
- 1 September 1978
Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins
A nondissociable tethered dithiane compound (1,2-dithiane-4,5-diol, 1,1-dioxide, cis; NSC 624151) has been identified, which specifically attacks the retroviral zinc fingers, but not other antiviral targets.
Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction.
- M. Cushman, W. Gołębiewski, W. Rice
- BiologyJournal of Medicinal Chemistry
- 16 September 1994
Although cosalane inhibits HIV-1 reverse transcriptase and protease, time of addition experiments indicate that it prevents the cytopathic effect of HIV by acting earlier than reverse transcription in the viral replication cycle.
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
- S. S. Yang, G. Cragg, D. Newman, J. Bader
- Biology, ChemistryJournal of Natural Products
- 6 January 2001
A retrospective review describes some of the anti-HIV lead discovery and development that took place under DTP auspices or which was substantially facilitated by resources made available through the DTP.
THE ROLE OF DEOXYRIBONUCLEIC ACID IN THE SYNTHESIS OF ROUS SARCOMA VIRUS.
- J. Bader
- Biology, ChemistryVirology
- 1 April 1964
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein
- W. Rice, J. Turpin, E. Sausville
- BiologyNature Network Boston
- 1 March 1997
Nucleocapsid p7 (NCp7) proteins of human immunodeficiency virus type 1 (HIV-1) contain two zinc binding domains of the sequence Cys-(X)2-Cys-(X)4-His-(X)4-Cys (CCHC)1,2. The spacing pattern and…
Studies on the relationship between glycolysis and (Na+ + K+)-ATPase in cultured cells.
- R. Balaban, J. Bader
- Biology, ChemistryBiochimica et Biophysica Acta
- 17 August 1984
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