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Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
TLDR
It is demonstrated that EAA stimulate MPS independently of increased insulin availability, and in the elderly, a deficit in MPS in the basal state is unlikely; and the decreased sensitivity and responsiveness of MPS to EAA, associated with decrements in the expression and activation of components of anabolic signaling pathways, are probably major contributors to the failure of muscle maintenance inThe elderly. Expand
Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical muscle stimulation
TLDR
The data suggest that a specific signaling response to LFS is a specific activation of the AMPK‐PGC‐1α signaling pathway which may explain some endurance training adaptations. Expand
Extremely short duration high intensity interval training substantially improves insulin action in young healthy males
TLDR
The efficacy of a high intensity exercise protocol, involving only ~250 kcal of work each week, to substantially improve insulin action in young sedentary subjects is remarkable and can be used as a strategy to reduce metabolic risk factors in young and middle aged sedentary populations who otherwise would not adhere to time consuming traditional aerobic exercise regimes. Expand
Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training
TLDR
It is shown that a novel, feasible exercise intervention can improve metabolic health and aerobic capacity and REHIT may offer a genuinely time-efficient alternative to HIT and conventional cardiorespiratory exercise training for improving risk factors of T2D. Expand
Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise
TLDR
There is a rapid increase in collagen synthesis after strenuous exercise in human tendon and muscle, and the similar time course of changes of protein synthetic rates in different cell types supports the idea of coordinated musculotendinous adaptation. Expand
Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions.
TLDR
A more rapid rise in MPS after maximal LC could translate into greater protein accretion and muscle hypertrophy during chronic resistance training utilizing maximal LC. Expand
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
TLDR
It would appear that miRNAs can produce marked changes in target protein abundance in vivo by working in a combinatorial manner, and miRNA detection represents a new molecular biomarker strategy for insulin resistance, where micrograms of patient material is needed to monitor efficacy during drug or life-style interventions. Expand
Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise.
TLDR
Short-term dynamic exercise in either shortening or lengthening mode increases MPS at least as much as resistance exercise and is associated with long-term activation of PKB and p70(S6K). Expand
No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise.
TLDR
Creatine supplementation increased muscle total creatine by approximately 21% and exercise increased the synthetic rates of myofibrillar and sarcoplasmic proteins by two- to threefold, and leg phenylalanine balance became more positive, but creatine was without any anabolic effect. Expand
Tendon collagen synthesis at rest and after exercise in women.
TLDR
Both in the resting state and after exercise, tendon collagen FSR is lower in women than in men, which may contribute to a lower rate of tissue repair after exercise. Expand
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