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Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration.
Genetic deficiencies demonstrate that both L FA-1 and Mac-1 contribute to adhesion of neutrophils to endothelial cells and ICAM-1, but adhesion through LFA-1 overshadows the contribution from Mac- 1.
Macrophage and dendritic cell phenotypic diversity in the context of biomaterials.
The interconnection between innate and adaptive immunity, the comparative and contrasting phenotypes and roles of Mϕs and DCs in immunity, their responses to biomaterials and the strategies to modulate their phenotype for applications in tissue engineering and vaccine delivery are discussed.
Differential levels of dendritic cell maturation on different biomaterials used in combination products.
- J. Babensee, Abhijit Paranjpe
- Biology, EngineeringJournal of biomedical materials research. Part A
- 15 September 2005
A differential effect of the biomaterial on which iDCs were cultured was observed as far as the extent of induced DC maturation, which is a novel biocompatibility selection and design criteria for biomaterials to be used in combination products in which immune consequences are potential complications or outcomes.
Differential effects of agarose and poly(lactic-co-glycolic acid) on dendritic cell maturation.
Application of biomaterials in combination products in which the biomaterial is presented to the host with a biological component prompts the need for understanding the biomaterial-associated…
Poly(lactic-co-glycolic acid) enhances maturation of human monocyte-derived dendritic cells.
- Mutsumi Yoshida, J. Babensee
- Biology, MedicineJournal of biomedical materials research. Part A
- 1 October 2004
Results suggest that PLGA is aDC maturation stimulus and that the form of the biomaterial may influence the extent of DC maturation.
Growth Factor Delivery for Tissue Engineering
The characteristic properties of growth factors are described to provide a biological basis for their use in tissue engineered devices and a review of experimental evidence illustrates examples of growth factor delivery from devices such as micropaticles, scaffolds, and encapsulated cells, for theirUse in the application of musculoskeletal tissue, neural tissue, and hepatic tissue.
Differential functional effects of biomaterials on dendritic cell maturation.
Interaction of dendritic cells with biomaterials.
- J. Babensee
- Biology, Materials ScienceSeminars in immunology
- 1 April 2008
Effect of poly(lactic-co-glycolic acid) contact on maturation of murine bone marrow-derived dendritic cells.
- Mutsumi Yoshida, Jessica Mata, J. Babensee
- BiologyJournal of biomedical materials research. Part A
It is suggested that PLGA contact induces maturation of murine DCs, supporting the observations with human DCs and the techniques developed in this study and given the results.