• Publications
  • Influence
Subchronic and chronic inhalation toxicity of antimony trioxide in the rat.
Under the exposure conditions of the current study, Sb2O3 was not a carcinogen and there were no Sb 2O3 effects on clinical chemistry or hematology in either study.
Blood levels of fluorocarbon related to cardiac sensitization.
Despite a tenfold difference in the inspired concentration of the two compounds, the blood concentrations associated with cardiac sensitization were similar for both agents.
Subchronic inhalation toxicity of methanol.
Overall, these findings support the use of the present American Council of Governmental Industrial Hygienists threshold limit value (TLV) of 200 ppm and short-term exposure limit (STEL) of 250 ppm for exposure to methanol vapor.
Evaluation of the subchronic and reproductive effects of a series of chlorinated propanes in the rat. I. Toxicity of 1,2,3-trichloropropane.
Repeated inhalation exposure and 1-generation reproduction studies have been conducted in the rat to address the adequacy of the 10 ppm occupational exposure limit established for
Toxicological evaluation of μ‐agonists part I: Assessment of toxicity following 30 days of repeated oral dosing of male and female rats with levo‐alpha‐acetylmethadol HCl (LAAM)
This study evaluated levo‐alpha‐acetylmethadol hydrochloride (LAAM), a long‐acting morphine‐like (μ) agonist approved in 1993 to treat opiate dependence, finding that death was dose‐dependent and Histopathological findings observed in kidneys and livers had abated.
Subchronic inhalation toxicity of ethylbenzene in mice, rats, and rabbits.
A no observed adverse effect level (NOAEL) of 382 ppm appears appropriate for rats and mice with a lowest observed adverseEffect level (LOAEL), and a NOAEL of 782 ppm and LOAel of 1610 ppm are appropriate for rabbits.
Toxic gases from fires.
Increasing use of a variety of synthetic polymers has stimulated interest in screening tests to evaluated the toxicity of polymeric materials when thermally decomposed, but this country lacks a standardized fire toxicity test protocol.
Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit.
The rabbit is the more sensitive species to the subchronic toxicological effects from EGEE, and mean body weight values for low- and high- dose animals were decreased; the mid-dose animals, however, showed no change.
Subchronic inhalation toxicity of p-nitroaniline and p-nitrochlorobenzene in rats.
Neither PNA nor PNCB exhibited significant toxicological effects other than those of methemoglobinemia, anemia, and splenic changes classically associated with nitroaromatics at levels significantly above presently accepted occupational standard.
Assessment of toxicity of o-nitrochlorobenzene in rats following a 4-week inhalation exposure.
The data suggest that the toxicity of ONCB is comparable to that of its structural analog, p-nitrochlorobenzene, and these two compounds should have similar work-place exposure limits.