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Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways.
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme activated by various phytochemicals and we examined the ability of Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, toExpand
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Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein.
Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde that is present in cigarette smoke. Heme oxygenase-1 (HO-1) is a cytoprotective enzyme activated by various such electrophilicExpand
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NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice.
Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival. WeExpand
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Temporal and mechanistic tracking of cellular uptake dynamics with novel surface fluorophore-bound nanodiamonds.
Nanoparticles (NPs) offer promise for a multitude of biological applications including cellular probes at the bio-interface for targeted delivery of anticancer substances, Raman and fluorescent-basedExpand
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Object and spatial imagery dimensions in visuo-haptic representations
Visual imagery comprises object and spatial dimensions. Both types of imagery encode shape but a key difference is that object imagers are more likely to encode surface properties than spatialExpand
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Neuroprotective role of retinal SIRT3 against acute photo-stress
SIRT3 is a key regulator of mitochondrial reactive oxygen species as well as mitochondrial function. The retina is one of the highest energy-demanding tissues, in which the regulation of reactiveExpand
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Pancreatic carcinoma in children in japan
A case of pancreatic carcinoma in a 4‐year‐old Japanese girl is described. This tumor was histologically determined to be adenocarcinoma of the head of the pancreas. Eleven additional cases ofExpand
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Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss.
Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis. Early AMDExpand
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Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice.
Aging is a significant risk factor for impaired tissue functions and chronic diseases. Age-associated decline in systemic NAD+ availability plays a critical role in regulating the aging processExpand
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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration.
Macrophage aging is pathogenic in diseases of the elderly, including age-related macular degeneration (AMD), a leading cause of blindness in older adults. However, the role of microRNAs, whichExpand
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