J. B. Flexner

Publications54
h-index25
Citations2,326
Highly Influential Citations8
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Memory in Mice as Affected by Intracerebral Puromycin
The antibiotic, puromycin, caused loss of memory of avoidance discrimination learning in mice when injected intracerebrally. Bilateral injections of puromycin involving the hippocampi and adjacent… Expand
Memory in Mice Analyzed with Antibiotics
It is apparent that antibiotics are useful in differentiating different stages in the formation of memory. Puromycin gave the first indication that very early memory can be established and survive,… Expand
INHIBITION OF PROTEIN SYNTHESIS IN BRAIN AND LEARNING AND MEMORY FOLLOWING PUROMYCIN *
ON the assumption that learning and memory may have a biochemical basis, the suggestion has become increasingly frequent during recent years that they may depend in some way on macromolecules such as… Expand
LOSS OF RECENT MEMORY IN MICE AS RELATED TO REGIONAL INHIBITION OF CEREBRAL PROTEIN SYNTHESIS.
Memory and cerebral protein synthesis in mice as affected by graded amounts of puromycin.
Abstract The effects of intracerebral injections of graded amounts of puromycin on memory and on degree and duration of inhibition of cerebral protein synthesis have been studied in the mouse. As the… Expand
Biochemical and physiological differentiation during morphogenesis. XVI. Cytochrome oxidase, succinic dehydrogenase and succinoxidase in the developing cerebral cortex and liver of the fetal guinea…
Biochemical and physiological differentiation during morphogenesis. XIX. Alkaline phosphatase and aldolase activities in the developing cerebral cortex and liver of the fetal guinea pig.
Biochemical and physiological differentiation during morphogenesis; the extracellular and intracellular phases of the liver and cerebral cortex of the fetal guinea pig as estimated from distribution…
Lactic dehydrogenases of the developing cerebral cortex and liver of the mouse and guinea pig.
Abstract Using cellulose ion exchangers and starch gel electrophoresis, four components of LDH have been found in the cerebral cortex of mouse and guinea pig. The several components tested could also… Expand
Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.
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