• Publications
  • Influence
Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis.
TLDR
TSLP is identified as a candidate gene critically involved in EE susceptibility beyond its role in promoting T(H)2 responses, and the induction of the candidate gene in primary esophageal epithelial cells is examined. Expand
Functional Variant in the Autophagy-Related 5 Gene Promotor is Associated with Childhood Asthma
TLDR
Genetic variants in ATG5, including a functional promotor variant, are associated with childhood asthma, providing novel evidence for a role for AtG5 in childhood asthma. Expand
Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution.
TLDR
The findings suggest a possible role of TET1 methylation in asthmatic patients and response to TRAP. Expand
Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.
TLDR
These results provide new insights into the pathogenesis of eczema in high-risk children and support a protective role for early exposure to dog, especially among those carrying the CD14-159C/T SNP. Expand
Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways
TLDR
Keratinocytes are known to play a major role in barrier function due to their location in the epidermis, and skin barrier pathways such as the keratinocyte differentiation pathway play a key role in AD pathogenesis. Expand
Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility.
TLDR
It is suggested that early-life exposure to high DEP levels was associated with significantly increased asthma prevalence among allergic children but not among nonallergic children, and DEP exposure results in accumulation of allergen-specific TH2/TH17 cells in the lungs, potentiating secondary allergenic recall responses and promoting the development of allergic asthma. Expand
Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children
TLDR
IL4 was identified as having a role in asthma susceptibility in both African American and Caucasian children, and while IL4 SNPs were associated with asthma in asthmatic children with European and African ancestry, the relative contributions of the most replicated asthma-associated SNPs varied by ancestry. Expand
&bgr;‐Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid‐resistant TH2/TH17 responses
TLDR
It is reported that fungal exposure enhances allergen‐driven TH2 responses, promoting severe allergic asthma and provides a strong rationale for combination treatment strategies targeting IL‐17A for this subgroup of fungus‐exposed patients with difficult‐to‐treat asthma. Expand
Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response.
TLDR
A biological basis for poor corticosteroid treatment response is identified that can be used to distinguish a subgroup of asthmatic children who respond poorly to systemic corticosterone treatment. Expand
Unraveling the relationship between aeroallergen sensitization, gender, second‐hand smoke exposure, and impaired lung function
TLDR
The relationship between aeroallergen sensitization, gender, second‐hand smoke exposure, and impaired lung function is unraveled. Expand
...
1
2
3
4
5
...