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Staphylococcus aureus Panton‐Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome
A specific host signaling pathway that mediates PVL‐induced inflammation and cytotoxicity is analyzed, which has high relevance for CA‐MRSA‐associated and PVL-mediated pathogenic processes, such as necrotizing infections.
S100P Is a Novel Interaction Partner and Regulator of IQGAP1*
S100P is a novel Ca2+-dependent regulator of IQGAP1 that can down-regulate the function of IQgAP1 as a signaling intermediate by direct interaction.
Characterization of the Ca2+-regulated Ezrin-S100P Interaction and Its Role in Tumor Cell Migration*
- J. Austermann, A. Nazmi, C. Müller-Tidow, V. Gerke
- Biology, ChemistryJournal of Biological Chemistry
- 24 October 2008
A prometastatic role of ezrin and S 100P that had been proposed based on their overexpression in highly metastatic cancers is probably due to a direct interaction between the two proteins and the S100P-mediated activation of eZrin.
Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions.
Actin binding of ezrin is activated by specific recognition of PIP2-functionalized lipid bilayers.
- Matthias Janke, A. Herrig, J. Austermann, V. Gerke, C. Steinem, A. Janshoff
- Biology, ChemistryBiochemistry
- 27 February 2008
Analysis of mechanism of switching ezrin from the dormant to the active, F-actin binding state by recognition of PIP 2 indicates that activation of ezrina can occur as a consequence of P IP 2 binding and does not require additional cofactors.
Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases.
Cooperative adsorption of ezrin on PIP2-containing membranes.
- A. Herrig, Matthias Janke, J. Austermann, V. Gerke, A. Janshoff, C. Steinem
- 5 October 2006
It is proposed that the binding process of ezrin occurs in a positive cooperative manner when lateral interactions of the proteins on the membrane were taken into account and the kinetics obtained from time-resolved QCM readouts were simulated by employing a model developed by Minton.
MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes
- H. Wittkowski, J. Kuemmerle-Deschner, D. Foell
- Medicine, BiologyAnnals of the rheumatic diseases
- 8 September 2011
Monitoring of cellular systems involved in inflammatory cascades of the innate immunity was successfully applied to the IL-1-driven CAPS diseases, suggesting control of phagocyte activation.
S100 proteins in rheumatic diseases
A deeper understanding of this family of proteins could lead the way to diagnostic and prognostic biomarkers and novel therapeutic strategies, and targeting the mechanism of S100 protein secretion and the immunomodulatory effects of S 100 proteins are promising approaches for future therapeutic strategies.
S100-alarmins: potential therapeutic targets for arthritis
In murine models, the blockade of S100A8/S100A9 ameliorates inflammatory processes, including arthritis, and there are several lines of evidence that S100-alarmins may already be targeted in therapeutic approaches in man.