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An overlapping essential gene in the Potyviridae
The family Potyviridae includes >30% of known plant virus species, many of which are of great agricultural significance. These viruses have a positive sense RNA genome that is ≈10 kb long andExpand
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An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response
Influenza's Cryptic Constraint Because of the well-known pandemic potential of influenza viruses, it is important to understand the range of molecular interactions between the virus and its host.Expand
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Deletion of Selenoprotein P Alters Distribution of Selenium in the Mouse*
Selenoprotein P (Se-P) contains most of the selenium in plasma. Its function is not known. Mice with the Se-P gene deleted (Sepp −/−) were generated. Two phenotypes were observed: 1) Sepp −/−miceExpand
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Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production
The arterivirus family (order Nidovirales) of single-stranded, positive-sense RNA viruses includes porcine respiratory and reproductive syndrome virus and equine arteritis virus (EAV). TheirExpand
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NS1′ of Flaviviruses in the Japanese Encephalitis Virus Serogroup Is a Product of Ribosomal Frameshifting and Plays a Role in Viral Neuroinvasiveness
ABSTRACT Flavivirus NS1 is a nonstructural protein involved in virus replication and regulation of the innate immune response. Interestingly, a larger NS1-related protein, NS1′, is often detectedExpand
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Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme
Abstract Rat antizyme gene expression requires programmed, ribosomal frameshifting. A novel autoregulatory mechanism enables modulation of frameshifting according to the cellular concentrationExpand
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The signal for a leaky UAG stop codon in several plant viruses includes the two downstream codons.
Expression of the RNA replicase domain of tobacco mosaic virus (TMV) and certain protein-coding regions in other plant viruses, is mediated by translational readthrough of a leaky UAG stop codon. ItExpand
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Efficient −2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein
Programmed −1 ribosomal frameshifting (−1 PRF) is a gene-expression mechanism used to express many viral and some cellular genes. In contrast, efficient natural utilization of −2 PRF has not beenExpand
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Evidence of efficient stop codon readthrough in four mammalian genes
Stop codon readthrough is used extensively by viruses to expand their gene expression. Until recent discoveries in Drosophila, only a very limited number of readthrough cases in chromosomal genes hadExpand
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A dual-luciferase reporter system for studying recoding signals.
A new reporter system has been developed for measuring translation coupling efficiency of recoding mechanisms such as frameshifting or readthrough. A recoding test sequence is cloned in between theExpand
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