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STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage
The data suggest that photoreceptor protection in response to LIF can be directly mediated by activation of STAT3 in photoreceptors, and that at the time of neuroprotection, STAT3 but not extracellular signal‐regulated kinase 1 and 2 or the Akt pathways was active in LIF‐treated retinas.
Lens-specific VEGF-A expression induces angioblast migration and proliferation and stimulates angiogenic remodeling.
The results support the hypothesis that VEGF-A can initiate the process of vascularization by stimulating chemoattraction and proliferation of angioblasts and endothelial cells and that VPD-A expression can stimulate angiogenic remodeling, however, VEGf-A alone was not sufficient to direct blood vessel organization or maturation.
Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice.
- Y. Le, J. Ash, M. Al-Ubaidi, Ying Chen, Jian-xing Ma, Robert E Anderson
- Biology, MedicineMolecular vision
- 27 December 2004
Cone distribution and cone ERG analysis suggested that cone photoreceptors were normal in adult HRGP-cre mice, and transgenic mice that efficiently express Cre recombinase incone photoreceptor cells have normal cone distribution and function.
In Vivo Regulation of Phosphoinositide 3-Kinase in Retina through Light-induced Tyrosine Phosphorylation of the Insulin Receptor β-Subunit*
- R. V. Rajala, Mark E. McClellan, J. Ash, Robert E Anderson
- Biology, MedicineThe Journal of Biological Chemistry
- 8 November 2002
The physiological role of the in vivo mechanism of PI3K activation in the rodent retina may be to provide neuroprotection of the retina against light damage by activating proteins that protect against stress-induced apoptosis.
Effect of Anti-CXCL10 Monoclonal Antibody on Herpes Simplex Virus Type 1 Keratitis and Retinal Infection
The results suggest that CXCL10 expression in the eye initially orchestrates the inflammatory response to acute HSV-1 infection, which facilitates the spread of the virus to other restricted sites within the eye.
Preconditioning-induced protection from oxidative injury is mediated by leukemia inhibitory factor receptor (LIFR) and its ligands in the retina
- S. Chollangi, Jian-gang Wang, Aaron Martin, John Quinn, J. Ash
- Biology, MedicineNeurobiology of Disease
- 1 June 2009
Qualitative PCR techniques demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress.
Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps
- J. Duncan, E. Pierce, +8 authors M. Zarbin
- MedicineTranslational vision science & technology
- 1 July 2018
This research presents a novel and scalable approach, called “Smart Gene Regulation,” which aims to provide real-time information about the activity of the immune cells in the eyes of the visually-impaired.
Mouse opsin promoter-directed Cre recombinase expression in transgenic mice.
Characterization of candidate photoreceptor-specific Cre mice using immunohistochemistry and functional assays demonstrated that an efficient Cre-mediated recombination occurred in rod photorecept cells in one mouse line and a mosaic Cre- mediated recombination happened in rodPhotoreceptors and rod bipolar cells in another mouse line.
Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model
The BM microenvironment of type 1 diabetic mice can lead to changes in haematopoiesis, with generation of more monocytes and fewer EPCs contributing to development of microvascular complications and inhibition of GP130 activation may serve as a therapeutic strategy to improve the key aspects of this dysfunction.
Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1.
Results suggest that, although CCR5 plays a role in regulating leukocyte trafficking and control of virus burden, compensatory mechanisms are involved in preventing mortality following HSV-1 infection.