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Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.
Together the hMR and hGR provide unexpected functional diversity in which hormone-binding properties, target gene interactions, and patterns of tissue-specific expression may be used in a combinatorial fashion to achieve complex physiologic control. Expand
Kinetics of a human glutamate transporter
The results suggest that glutamate diffusion and binding to transporters, rather than uptake, are likely to dominate the synaptic concentration decay kinetics. Expand
A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radi
The array is flexible and integrally spring biased between hub and annulus to maintain the bottom walls of the cuvettes against the rotatable support with which the cuvette array is to be utilized under pressure to maximize contact therebetween. Expand
The neuronal mineralocorticoid eeceptor as a mediator of glucocorticoid response
In vitro assay for MR and GR function demonstrates that these receptors respond to different levels of glucocorticoid, suggesting that together they confer a larger dynamic range of sensitivity to this hormone, leading to a new hypothesis for glucoc Corticosteroid action in the central nervous system. Expand
Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide.
As a consequence of alternative RNA processing events, a single rat gene can generate messenger RNA's (mRNA's) encoding either calcitonin or a neuropeptide referred to as alpha-type calcitoninExpand
Excitatory Amino Acid Transporters of the Salamander Retina: Identification, Localization, and Function
The diverse population of sEAAT transporter subtypes with unique localization and functional properties indicates that glutamate transporters play a wide variety of roles in retinal function and are likely to underlie both the uptake of glutamate by Müller cells and the glutamate-elicited chloride conductance involved in signal transduction by photoreceptors and bipolar cells. Expand
Localization and function of five glutamate transporters cloned from the salamander retina
Five distinct glutamate transporters from the salamander retina are cloned and each behaved in a manner consistent with a glutamate transporter and there were some distinguishing characteristics which make it possible to link the function in native cells with the behavior of the clonedtransporters in this study. Expand
Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor.
Experiments revealed that the hMR amino-terminus does not provide the strong transactivation function present in the equivalent hGR domain and, in contrast to the hGR amino- terminus, interferes with the synergistic activity mediated by the DNA- and ligand-binding domains of both receptors. Expand
A molecular framework for the actions of glucocorticoid hormones in the nervous system
A new working hypothesis is presented-a “blnary hormone response system”-for the actions of glucocorticoids in the brain using recent analyses of the relationship of the minerdlocorticoid and glucocORTicoid receptors (the typ? I and type II corticosteroid receptors) found in the nervous system. Expand
Neurotransmitter transporters: three distinct gene families
Our understanding of the plasma membrane and vesicular transport systems that mediate neurotransmitter re-uptake has been greatly enhanced in the past year by the cloning and characterization of twoExpand