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Purification of gastroprotective triterpenoids from the stem bark of Amphipterygium adstringens; role of prostaglandins, sulfhydryls, nitric oxide and capsaicin-sensitive neurons.
The results suggest that endogenous nitric oxide plays an important role in the gastroprotection of A. adstringens methanol extract on ethanol-induced gastric mucosal lesions and that there is partial participation by prostaglandins and endogenous sulfhydryls. Expand
Gastroprotective effect of Astragaloside IV: role of prostaglandins, sulfhydryls and nitric oxide
The gastroprotection observed at 30 mg kg−1 for Astragaloside IV was attenuated in rats pretreated with NG‐nitro‐l‐arginine methyl ester, suggesting that the gastroprotective mechanism of this glycoside involves, at least in part, the participation of NO. Expand
Gastroprotection and effect of the simultaneous administration of Cuachalalate (Amphipterygium adstringens) on the pharmacokinetics and anti‐inflammatory activity of diclofenac in rats
The experimental findings in rats suggest that CME at doses lower than 100 mg kg−1 protects the gastric mucosa from the damage induced by diclofenac sodium without altering either the anti‐inflammatory activity or the pharmacokinetics of this NSAID. Expand
Bioassay‐guided isolation of an anti‐ulcer diterpenoid from Croton reflexifolius: role of nitric oxide, prostaglandins and sulfhydryls
Polyalthic acid, which was isolated from this plant, was the main compound with gastroprotector activity, having effectiveness similar to that found with the use of carbenoxolone. Expand
Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: role of nitric oxide, prostaglandins and sulfydryls.
The results show that E. aschenbornianum had gastroProtective activity, that the hexane extract had the highest protective activity, and that encecanescin isolated from this extract was the main active gastroprotective agent. Expand
Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats
Dillapiole was identified as the most active compound in this extract of P. pellucida using an ethanol-induced gastric ulcer experimental rat model and suggests that the gastroprotective mechanism of action of dillapIOle does not involve prostaglandins, NO or sulfhydryl groups. Expand
Gastroprotective activity of caryophyllene oxide: the role of nitric oxide, prostaglandins and sulfhydryls.
Article history: Received on: 14/08/2014 Revised on: 27/08/2014 Accepted on: 11/09/2014 Available online: 27/09/2014 The present study was carried out to evaluate the gastroprotective effect ofExpand
Role of Prostaglandins, Nitric oxide, Sulfhydryls and Capsaicin-sensitive Neurons in Gastroprotection of Stigmasterol and β-Sitosterol
In this investigation the gastroprotective activity of stigmasterol and β-sitosterol was evaluated. Gastric mucosal damage was induced in rats by intragastric ethanol (1 mL/rat). Rats treated orallyExpand
Dynamics of Soil Oribatids (Acari) in a Tropical Regeneration Ecosystem of Costa Rica.
Population dynamics of four Oribatid mites species are analyzed for further purposes of soil health on three different restoration habitat regime in the Lankester Botanical Garden, Costa Rica. AExpand
Neuropharmacological profile of hydroalcohol extract of Valeriana edulis ssp. procera roots in mice
The results allowed the conclusion that the extract of V. edulis has central nervous depressant properties similar to, but with some differences to V. officinalis, a very well known species and underlie the medical and industrial use of this species. Expand