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Do Novel Antipsychotics Have Similar Pharmacological Characteristics? A Review of the Evidence
Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator
- Kenji Maeda, Haruhiko Sugino, T. Kikuchi
- Biology, ChemistryThe Journal of Pharmacology and Experimental…
- 1 September 2014
Based on a lower intrinsic activity at D2 receptors and higher binding affinities for 5-HT1A/2A receptors than aripiprazole, brexpiprazoles would have a favorable antipsychotic potential without D2 receptor agonist- and antagonist-related adverse effects.
Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine.
- J. Arnt
- Biology, PsychologyEuropean journal of pharmacology
- 5 September 1995
Inactivation of 5-HT2C Receptors Potentiates Consequences of Serotonin Reuptake Blockade
Using in vivo microdialysis methods in rats, the nonselective 5-HT2 receptor antagonist ketanserin was observed to produce a robust augmentation of citalopram-, fluoxetine-, and sertraline-induced elevations of hippocampal extracellular serotonin levels.
Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro.
Reversal of Subchronic PCP-Induced Deficits in Attentional Set Shifting in Rats by Sertindole and a 5-HT6 Receptor Antagonist: Comparison Among Antipsychotics
- J. Rodefer, T. N. Nguyen, J. Karlsson, J. Arnt
- Psychology, MedicineNeuropsychopharmacology
- 1 October 2008
The data suggest that the combination of 5-HT6 antagonistic activity and the absence of antimuscarinic activity may represent key characteristics of the pharmacological profile for improved antipsychotic drugs for schizophrenia.
Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics.
Pharmacological specificity of conditioned avoidance response inhibition in rats: inhibition by neuroleptics and correlation to dopamine receptor blockade.
- J. Arnt
- Psychology, BiologyActa pharmacologica et toxicologica
- 13 March 2009
It is concluded that CAR inhibition is a sensitive test for dopamine receptor antagonists, however, additional alpha-adrenergic activity found for some neuroleptics may contribute to the CAR inhibitory potency.
Effects of the 5-HT6 receptor antagonist, SB-271046, in animal models for schizophrenia
Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
- J. Arnt, B. Bang-Andersen, L. Witten
- Biology, ChemistryThe international journal of…
- 1 September 2010
Lu AE58054 is a selective antagonist of 5-HT(6)Rs with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia, and may be useful for the pharmacotherapy of cognitive dysfunction in disease states such as schizophrenia and Alzheimer's disease.