Adolescent Rats Find Repeated Δ9-THC Less Aversive Than Adult Rats but Display Greater Residual Cognitive Deficits and Changes in Hippocampal Protein Expression Following Exposure
It is suggested that adolescent rats find repeated Δ9-THC exposure less aversive than adults, but that cannabinoid exposure causes greater lasting memory deficits and hippocampal alterations in adolescent than adult rats.
A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice.
- Leonora E. Long, R. Chesworth, Xu-Feng Huang, I. McGregor, J. Arnold, T. Karl
- Biology, PsychologyInternational Journal of Neuropsychopharmacology
- 1 August 2010
First evidence of anxiolytic- and antipsychotic-like effects of chronic but not acute CBD in C57BL/6JArc mice is provided, extending findings from acute studies in other inbred mouse strains and rats.
Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
CBD can potentiate the psychoactive and physiological effects of THC in rats, most likely by delaying the metabolism and elimination of THC through an action on the CYP450 enzymes that metabolise both drugs.
Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats.
Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats
Overall these results suggest that exogenous OT administered during adolescence can have subtle yet enduring effects on anxiety, sociability and the motivation to consume alcohol.
Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus
Examination of patterns of neural activation produced by methamphetamine were modified by co‐administered oxytocin to demonstrate the capacity of peripherally administered oxytoc in to induce widespread central effects and provide new evidence for central actions of peripheral oxytocIn.
Analysis of Cannabis Seizures in NSW, Australia: Cannabis Potency and Cannabinoid Profile
The present analysis echoes trends reported in other countries towards the use of high potency cannabis with very low CBD content, which is thought by some to predispose to greater adverse outcomes on mental health and fewer therapeutic benefits.
The role of endocannabinoid transmission in cocaine addiction
- J. Arnold
- Biology, PsychologyPharmacology, Biochemistry and Behavior
- 1 June 2005
Enhanced Brain Disposition and Effects of Δ9-Tetrahydrocannabinol in P-Glycoprotein and Breast Cancer Resistance Protein Knockout Mice
Results show P-gp and Bcrp prolong the brain disposition and hypothermic effects of THC and offer a novel mechanism for both genetic vulnerability to the psychoactive effects of cannabis and drug interactions between CNS therapies and cannabis.
Stress-Induced Grey Matter Loss Determined by MRI Is Primarily Due to Loss of Dendrites and Their Synapses
This quantitative study is the first to relate GMV changes in the cortex measured with MRI to volume changes in cellular constituents of the grey matter.