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Dopamine D1 and D2 mediation of the discriminative stimulus properties ofd-amphetamine and cocaine
Evidence suggests that stimulants such asd-amphetamine and cocaine act presynaptically by increasing the amount of dopamine (DA) available to stimulate postsynaptic DA receptors. Since twoExpand
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Effects of stimulation and blockade of dopamine receptor subtypes on the discriminative stimulus properties of cocaine
The involvement of dopamine (DA) receptor subtypes in the behavioral effects of CNS stimulants was studied in rats trained to discriminate occaine from saline. In substitution tests, the stimulusExpand
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Increasing the Selectivity of Drug Discrimination Procedures
In an attempt to increase the selectivity of drug discrimination, rats were trained to discriminate LSD (0.08 mg/kg) from a group of "other" compounds consisting of cocaine (10 mg/kg), pentobarbitalExpand
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Neuropharmacological reassessment of the discriminative stimulus properties ofd-lysergic acid diethylamide (LSD)
The neuropharmacological mechanisms underlying the behavioral effects ofd-lysergic acid diethylamide (LSD) were assessed by comparing the discriminative stimulus properties of LSD with those ofExpand
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Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT) has effects both characteristic of a serotonin (5-hydroxytryptamine; 5-HT) agonist and antagonist. To investigate the mechanism(s) of action ofExpand
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Lysergic acid diethylamide (LSD) and lisuride: differentiation of their neuropharmacological actions.
The nonhallucinogenic ergot derivative lisuride exerts many pharmacological effects that are similar to those of its hallucinogenic congener, lysergic acid diethylamide (LSD). Animals trained toExpand
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Involvement of dopamine uptake in the discriminative stimulus effects of cocaine1,2
The involvement of dopaminergic and adrenergic mechanisms in the stimulus effects of cocaine was studied in rats trained to discriminate cocaine from saline. The cocaine (10 mg/kg) cue generalized toExpand
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Variable-interval punishment during variable-interval reinforcement.
  • Y. Filby, J. Appel
  • Psychology, Medicine
  • Journal of the experimental analysis of behavior
  • 1 September 1966
Variable-interval punishment was superimposed on a variable-interval food reinforcement baseline for three groups of rats. The value for the variable-interval punishment schedule was the same as thatExpand
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Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline.
In order to further evaluate the extent to which particular 5-HT receptor subtypes (5-HT1, 5-HT2) might be involved in the behavioral effects of hallucinogenic drugs, rats were trained toExpand
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Stimulus properties of dopaminergic drugs: comparisons involving selective agonists and antagonists.
Rats were trained to discriminate the putatively selective dopamine (DA) receptor agonists SKF 38393 (10 mg/kg) or Ly 171555 (0.025 mg/kg) from saline in a two-lever situation involving fixed-ratioExpand
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