J. Appel

Publications78
h-index21
Citations2,856
Highly Influential Citations26
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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
EXISTING methods for the synthesis and screening of large numbers of peptides are limited by their inability to generate and screen the requisite number (millions) of individual peptides1–4 and/or… Expand
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Hospital-based comprehensive cardiac rehabilitation versus usual care among patients with congestive heart failure, ischemic heart disease, or high risk of ischemic heart disease: 12-month results of…
BACKGROUND Current guidelines broadly recommend comprehensive cardiac rehabilitation (CCR), although evidence for this is still limited. We investigated the 12-month effect of hospital-based CCR… Expand
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Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.
We describe here a conceptually unique set of individual synthetic peptide combinatorial libraries (SPCLs), termed a positional scanning SPCL (PS-SPCL), that can be used for the rapid (i.e., a single… Expand
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Mixture-based synthetic combinatorial libraries.
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Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
Since its inception more than 20 years ago with highthroughput parallel synthesis for oligonucleotides and peptides, synthetic combinatorial methods have fundamentally advanced the ability to… Expand
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The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells.
T cells identify by their T-cell receptor (TCR) short peptides in the context of major histocompatibility complex (MHC) molecules. The interaction of the trimolecular complex composed of the TCR and… Expand
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Elucidation of discontinuous linear determinants in peptides.
Synthetic peptides, made by the method of simultaneous multiple peptide synthesis, were coupled to the protein carrier keyhole limpet hemocyanin and used to raise mAb. Omission and substitution… Expand
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Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries
The conceptual and technical approaches that led to the explosive growth of combinatorial chemistry began approximately 20 years ago. In the past decade, combinatorial chemistry has continued to… Expand
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The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells
The proprotein convertases (PCs) play an important role in protein precursor activation through processing at paired basic residues. However, significant substrate cleavage redundancy has been… Expand
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Selective Agonists and Antagonists of Formylpeptide Receptors: Duplex Flow Cytometry and Mixture-Based Positional Scanning Libraries
The formylpeptide receptor (FPR1) and formylpeptide-like 1 receptor (FPR2) are G protein–coupled receptors that are linked to acute inflammatory responses, malignant glioma stem cell metastasis, and… Expand
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