Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
- R. Houghten, C. Pinilla, S. Blondelle, J. Appel, C. Dooley, J. Cuervo
- Biology, Medicine
- Nature
- 7 November 1991
EXISTING methods for the synthesis and screening of large numbers of peptides are limited by their inability to generate and screen the requisite number (millions) of individual peptides1–4 and/or… Expand
Hospital-based comprehensive cardiac rehabilitation versus usual care among patients with congestive heart failure, ischemic heart disease, or high risk of ischemic heart disease: 12-month results of…
- Ann-Dorthe Zwisler, A. M. Soja, +9 authors J. Fischer-Hansen
- Medicine
- American heart journal
- 1 June 2008
BACKGROUND
Current guidelines broadly recommend comprehensive cardiac rehabilitation (CCR), although evidence for this is still limited. We investigated the 12-month effect of hospital-based CCR… Expand
Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.
- C. Pinilla, J. Appel, P. Blanc, R. Houghten
- Biology, Medicine
- BioTechniques
- 1 December 1992
We describe here a conceptually unique set of individual synthetic peptide combinatorial libraries (SPCLs), termed a positional scanning SPCL (PS-SPCL), that can be used for the rapid (i.e., a single… Expand
Mixture-based synthetic combinatorial libraries.
- R. Houghten, C. Pinilla, +5 authors J. Ostresh
- Chemistry, Medicine
- Journal of medicinal chemistry
- 23 September 1999
Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
- R. Houghten, C. Pinilla, +9 authors Jeff Schneider
- Chemistry, Medicine
- Journal of combinatorial chemistry
- 2008
Since its inception more than 20 years ago with highthroughput parallel synthesis for oligonucleotides and peptides, synthetic combinatorial methods have fundamentally advanced the ability to… Expand
The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells.
- B. Hemmer, C. Pinilla, J. Appel, J. Pascal, R. Houghten, R. Martin
- Biology, Medicine
- The journal of peptide research : official…
- 12 January 2009
T cells identify by their T-cell receptor (TCR) short peptides in the context of major histocompatibility complex (MHC) molecules. The interaction of the trimolecular complex composed of the TCR and… Expand
Elucidation of discontinuous linear determinants in peptides.
- J. Appel, C. Pinilla, H. Niman, R. Houghten
- Chemistry, Medicine
- Journal of immunology
- 1 February 1990
Synthetic peptides, made by the method of simultaneous multiple peptide synthesis, were coupled to the protein carrier keyhole limpet hemocyanin and used to raise mAb. Omission and substitution… Expand
Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries
- C. Pinilla, J. Appel, Eva Borràs, R. Houghten
- Engineering, Medicine
- Nature Medicine
- 2003
The conceptual and technical approaches that led to the explosive growth of combinatorial chemistry began approximately 20 years ago. In the past decade, combinatorial chemistry has continued to… Expand
The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells
- C. Levesque, M. Fugère, +12 authors R. Day
- Chemistry, Medicine
- Journal of medicinal chemistry
- 5 November 2012
The proprotein convertases (PCs) play an important role in protein precursor activation through processing at paired basic residues. However, significant substrate cleavage redundancy has been… Expand
Selective Agonists and Antagonists of Formylpeptide Receptors: Duplex Flow Cytometry and Mixture-Based Positional Scanning Libraries
- C. Pinilla, B. Edwards, +7 authors R. Houghten
- Chemistry, Medicine
- Molecular Pharmacology
- 1 September 2013
The formylpeptide receptor (FPR1) and formylpeptide-like 1 receptor (FPR2) are G protein–coupled receptors that are linked to acute inflammatory responses, malignant glioma stem cell metastasis, and… Expand