J. Appel

Publications88
h-index24
Citations3,361
Highly Influential Citations39
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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
TLDR
The precise identification of an antigenic determinant recognized by a monoclonal antibody as well as the straightforward development of new potent antimicrobial peptides are presented.
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Polyarginines Are Potent Furin Inhibitors*
TLDR
The identification of non-acetylated, poly-d-arginine-derived molecules may represent excellent lead compounds for the development of therapeutically useful furin inhibitors, and they are shown to show extended subsite recognition by furin and PC2.
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Identification of Inhibitors of Prohormone Convertases 1 and 2 Using a Peptide Combinatorial Library*
TLDR
A positional scanning synthetic peptide combinatorial library was used to identify potential inhibitory peptides for recombinant mouse prohormone convertase 1 (PC1) and PC2 and to provide information on the specificity of these enzymes, finding the most potent inhibitor to be the same peptide for both enzymes.
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Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.
TLDR
A conceptually unique set of individual synthetic peptide combinatorial libraries (SPCLs) that can be used for the rapid identification of peptide sequences that bind with high affinity to antibodies, receptors or other acceptor molecules are described.
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Short Polybasic Peptide Sequences Are Potent Inhibitors of PC5/6 and PC7: Use of Positional Scanning-Synthetic Peptide Combinatorial Libraries as a Tool for the Optimization of Inhibitory Sequences
TLDR
It is concluded that basic residues within PC peptide inhibitors might be responsible for targeting PCs in general and for inhibitory potency, but that select amino acid changes will be necessary to acquire true specificity toward a single PC.
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The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells
TLDR
It is concluded that peptide-based inhibitors can yield specific PC inhibitors and that the ML-peptide is an important lead compound that could potentially have applications in prostate cancer.
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Mixture-based synthetic combinatorial libraries.
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Selective Agonists and Antagonists of Formylpeptide Receptors: Duplex Flow Cytometry and Mixture-Based Positional Scanning Libraries
TLDR
High-throughput assays using mixture-based combinatorial libraries represent a unique, highly efficient approach for rapid data acquisition and ligand identification and Comparative analyses of other previous screening approaches clearly illustrate the efficiency of identifying receptor selective, individual compounds from mixture- based combinatorsial libraries.
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Elucidation of discontinuous linear determinants in peptides.
TLDR
Results suggest that, at the amino acid level, all antigenic determinants of synthetic peptides defined by mAb can be considered discontinuous linear determinants.
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Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries
TLDR
The conceptual and practical breakthroughs that have been critical for the development of synthetic combinatorial methods are described and includes the most recent developments and applications of mixture-based combinatorsial libraries.
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